93585-83-2

Basic information

• Product Name: helospectin II
• Synonyms: HelospectinI, 38-de-L-serine-; 10: PN: WO0077039 TABLE: 1 unclaimed protein; 10: PN:WO2004005342 PAGE: 46 claimed protein; 3: PN: WO0234285 SEQID: 11 claimedprotein; 6: PN: US6284725 SEQID: 11 unclaimed protein; 6: PN: WO0066138 PAGE:13 unclaimed protein; 6: PN: WO0066142 TABLE: 1 unclaimed protein; L-Serine,L-histidyl-L-seryl-L-a-aspartyl-L-alanyl-L-threonyl-L-phenylalanyl-L-threonyl-L-alanyl-L-a-glutamyl-L-tyrosyl-L-seryl-L-lysyl-L-leucyl-L-leucyl-L-alanyl-L-lysyl-L-leucyl-L-alanyl-L-leucyl-L-glutaminyl-L-lysyl-L-tyrosyl-L-leucyl-L-a-glutamyl-L-seryl-L-isoleucyl-L-leucylglycyl-L-seryl-L-seryl-L-threonyl-L-seryl-L-prolyl-L-arginyl-L-prolyl-L-prolyl-
• CAS NO: 93585-83-2
• Molecular Formula: C180H288N46O57
• Molecular Weight: 4008.48672
• Mol File: 93585-83-2.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: helospectin II(CAS DataBase Reference)
• NIST Chemistry Reference: helospectin II(93585-83-2)
• EPA Substance Registry System: helospectin II(93585-83-2)

Safety Data

• Hazardous Substances Data: 93585-83-2(Hazardous Substances Data)

Usage

General Description

Helospectin II is a neurotoxin found in the venom of the spider Agelena orientalis. This peptide consists of 32 amino acid residues and has been shown to specifically target and block certain types of calcium channels in the nervous system, leading to paralysis and death in potential prey. Helospectin II is structurally similar to omega-agatoxin IVA, a calcium channel blocker found in the venom of the funnel-web spider, but exhibits differences in its binding properties and activity. Research on helospectin II has provided valuable insights into the mechanisms of venom toxicity and potential applications in the development of new pharmaceuticals targeting calcium channels.