936917-36-1 Usage
Description
1-azido-2-(2-(2-(2-iodoethyoxy)ethoxy)ethoxy)ethane, also known as Iodo-PEG3-Azide, is a PEG (polyethylene glycol) linker that incorporates iodide and azide functional groups. The hydrophilic PEG spacer enhances its solubility in aqueous environments, while the azide group is capable of reacting with alkyne, BCN, and DBCO through Click Chemistry, resulting in a stable triazole linkage. The iodide acts as an effective leaving group, facilitating nucleophilic substitution reactions.
Uses
Used in Bioconjugation:
1-azido-2-(2-(2-(2-iodoethyoxy)ethoxy)ethane is used as a bioconjugation agent for the attachment of biomolecules to various surfaces or other molecules. The azide group enables the formation of stable triazole linkages through Click Chemistry, allowing for precise and efficient bioconjugation.
Used in Drug Delivery Systems:
In the pharmaceutical industry, 1-azido-2-(2-(2-(2-iodoethyoxy)ethoxy)ethane is used as a component in drug delivery systems. The PEG spacer and hydrophilic nature of the molecule contribute to improved solubility and bioavailability of drugs, while the iodide group can be utilized for further functionalization or modification of the drug delivery system.
Used in Contrast Agents for Medical Imaging:
1-azido-2-(2-(2-(2-iodoethyoxy)ethoxy)ethane is used as a component in contrast agents for medical imaging. The presence of the iodide group allows for enhanced imaging contrast in techniques such as X-ray computed tomography (CT) and magnetic resonance imaging (MRI), improving the visualization of internal structures and aiding in the diagnosis of various medical conditions.
Used in Chemical Synthesis:
In the field of organic chemistry, 1-azido-2-(2-(2-(2-iodoethyoxy)ethoxy)ethane is used as an intermediate in the synthesis of various complex organic molecules. The versatility of the PEG linker and the reactivity of the azide and iodide groups make it a valuable building block for the creation of novel compounds with diverse applications.
Check Digit Verification of cas no
The CAS Registry Mumber 936917-36-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,3,6,9,1 and 7 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 936917-36:
(8*9)+(7*3)+(6*6)+(5*9)+(4*1)+(3*7)+(2*3)+(1*6)=211
211 % 10 = 1
So 936917-36-1 is a valid CAS Registry Number.
936917-36-1Relevant articles and documents
Discovery of 3,3′-pyrrolidinyl-spirooxindoles as cardioprotectant prohibitin ligands
Elderwish, Sabria,Audebrand, Ana?s,Nebigil, Canan G.,Désaubry, Laurent
supporting information, (2019/11/26)
The scaffold proteins prohibitins-1 and 2 (PHB1/2) play many important roles in coordinating many cell signaling pathways and represent emerging targets in cardiology and oncology. We previously reported that a family of natural products derivatives, flavaglines, binds to PHB1/2 to exert cardioprotectant and anti-cancer effects. However, flavaglines also target the initiation factor of translation eIF4A, which doesn't contribute to cardioprotection and may even induce some adverse effects. Herein, we report the development of a convenient and robust synthesis of the new PHB2 ligand 2′-phenylpyrrolidinyl-spirooxindole, and its analogues. We discovered that these compounds displays cardioprotective effect against doxorubicin mediated cardiotoxicity and uncovered the structural requirement for this activity. We identified in particular some analogues that are more cardioprotectant than flavaglines. Pull-down experiments demonstrated that these compounds bind not only to PHB2 but also PHB1. These novel PHB ligands may provide the basis for the development of new drugs candidates to protect the heart against the adverse effects of anticancer treatments.
Tyrosine bioconjugation through aqueous ene-type reactions: A click-like reaction for tyrosine
Ban, Hitoshi,Gavrilyuk, Julia,Barbas III, Carlos F.
supporting information; experimental part, p. 1523 - 1525 (2010/04/03)
(Figure Presented) A new and versatile class of cyclic diazodicarboxamides that reacts efficiently and selectively with phenols and the phenolic side chain of tyrosine through an ene-like reaction is reported. This mild aqueous tyrosine ligation reaction works over a broad pH range and expands the repertoire of aqueous chemistries available for small molecule, peptide, and protein modification. The tyrosine ligation reactions are shown to be compatible with the labeling of native enzymes and antibodies in a buffered aqueous solution. This reaction provides a novel synthetic approach to bispecific antibodies. We believe this reaction will find broad utility in peptide and protein chemistry and in the chemistry of phenol-containing compounds.
