937389-80-5

Basic information

• Product Name: C₈₀H₁₀₂ClN₁₅O₁₃S
• Synonyms: C₈₀H₁₀₂ClN₁₅O₁₃S
• CAS NO: 937389-80-5
• Molecular Weight: 1549.3
• Mol File: 937389-80-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₈₀H₁₀₂ClN₁₅O₁₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₈₀H₁₀₂ClN₁₅O₁₃S(937389-80-5)
• EPA Substance Registry System: C₈₀H₁₀₂ClN₁₅O₁₃S(937389-80-5)

Safety Data

• Hazardous Substances Data: 937389-80-5(Hazardous Substances Data)

Upstream product

• 937389-72-5 C₈H₁₅NSO₄ 
• 108-24-7 acetic anhydride 
• 76985-10-9 Boc-D-2Nal-OH 
• 114346-31-5 (S)-3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid 
• 114346-31-5 (R)-3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid 
• 937389-76-9 C₈H₁₅NSO₄ 

Relevant articles and documents

Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized derivatives

A series of acyline analogues incorporating L- and D-isomers of S-arylated/alkylated norcysteines [Ncy(R), where R is 2-naphthyl, methyl, and isopropyl] at positions 1, 4, 7, and 10 were synthesized. Some of these analogues were mono- and dioxidized to sulfoxides and sulfones. All of the analogues of acyline were screened for the antagonism of the GnRH-induced response in a reporter gene assay in HEK-293 cells expressing the human GnRH receptor. Nine of the analogues (9, 11, 15, 16, 17, 19, 20, 21, and 22) had antagonistic potency (IC50 50 = 0.52 nM) in this assay. Selected analogues (9, 11, 15, 16, 19, and 21) were tested in vitro for their antagonism at the rat GnRH-R in a reporter gene assay as well as in an in vivo intact male rat assay. Analogues 9 and 15 were the most potent in suppressing testosterone levels.