939791-38-5 Usage
Description
PF-562271 is an ATP-competitive, reversible inhibitor of focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2), which are non-receptor tyrosine kinases that play a crucial role in various oncogenic pathways. It demonstrates high potency and selectivity for FAK, with an IC50 value of 1.5 nM, and 10-fold reduced potency for PYK2 (IC50 = 14 nM), along with >100-fold selectivity against other protein kinases.
Used in Pharmaceutical Industry:
PF-562271 is used as an anticancer agent for its ability to inhibit FAK phosphorylation, which is involved in tumor growth and progression. It has shown to regress tumors in multiple xenograft models and has an EC50 value of 93 ng/ml in glioblastoma-bearing mice.
Used in Drug Development:
PF-562271 is used as a research tool for studying the role of FAK and PYK2 in cancer and other diseases. Its high potency and selectivity make it a valuable compound for investigating the therapeutic potential of targeting these kinases in various pathological conditions.
Used in Cancer Therapy:
PF-562271 is used as a potential therapeutic agent for the treatment of various types of cancer, including glioblastoma, by targeting the FAK and PYK2 pathways, which are implicated in tumor growth, invasion, and metastasis.
Used in Drug Formulation:
PF 562271 Besylate is the besylate salt of PF-562271, which may improve the solubility and bioavailability of the compound, making it more suitable for pharmaceutical formulations and administration to patients.
Check Digit Verification of cas no
The CAS Registry Mumber 939791-38-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,3,9,7,9 and 1 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 939791-38:
(8*9)+(7*3)+(6*9)+(5*7)+(4*9)+(3*1)+(2*3)+(1*8)=235
235 % 10 = 5
So 939791-38-5 is a valid CAS Registry Number.
939791-38-5Relevant articles and documents
PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH
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, (2011/02/26)
The present invention relates to salts, solvates and substoichiometric solvates of N-[3-[[[2-[(2,3-dihydro-2-oxo-1H-indo1-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]-2-pyridinyl]-N-methylmethanesulfonamide. The invention also provides pharmaceutical compositions comprising such complexes, as well as methods of treating abnormal cell growth by administering the complexes of the invention.
