93987-29-2

Basic information

• Product Name: BI 6015
• Synonyms: BI 6015;2-Methyl-1-(2-methyl-5-nitrophenylsulfonyl)-1H-benzo[d]imidazole
• CAS NO: 93987-29-2
• Molecular Formula: C15H13N3O4S
• Molecular Weight: 331.34642
• Product Categories: Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
• Mol File: 93987-29-2.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: +2C to +8C
• Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml).
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
• CAS DataBase Reference: BI 6015(CAS DataBase Reference)
• NIST Chemistry Reference: BI 6015(93987-29-2)
• EPA Substance Registry System: BI 6015(93987-29-2)

Safety Data

• Hazardous Substances Data: 93987-29-2(Hazardous Substances Data)

Usage

Description

BI 6015 is a hepatocyte nuclear factor 4α (HNF4α) antagonist, which is a small molecule tool for pharmacological modulation of HNF4α activity. HNF4α is a central regulator of gene expression in cell types that play a crucial role in maintaining metabolic homeostasis. BI 6015 binds to HNF4α with high affinity and modulates the expression of known target genes. It has been shown to be selectively cytotoxic to cancer cell lines both in vitro and in vivo, although its in vivo potency is limited by suboptimal pharmacokinetics. BI 6015 is a cell permeable compound.

Uses

Used in Pharmaceutical Industry:
BI 6015 is used as a HNF4α antagonist for selectively repressing the expression of known HNF4α target genes. This selective cytotoxic activity makes it a potential candidate for the development of targeted cancer therapies.
BI 6015 is used as a research tool for studying the role of HNF4α in various cellular processes and its potential as a therapeutic target for metabolic disorders and cancer.
Used in Cancer Research:
BI 6015 is used as a selective cytotoxic agent against numerous tumor cell lines, providing a valuable tool for investigating the underlying mechanisms of cancer cell growth and survival.

References

1) Wang et al. (2000), Hepatocyte Nuclear Factor 4α Regulates the Expression of Pancreatic β-Cell Genes Implicated in Glucose Metabolism and Nutrient-induced Insulin Secretion; J. Biol. Chem., 275 35953 2) Kiselyuk et al. (2012), HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promotor; Chem. Biol., 19 806