940870-53-1

Basic information

• Product Name: 1-(2-(2-chloropyrimidin-4-yloxy)-5-fluorobenzyl)-3-(3-t-butyl-1-p-tolyl-1 H-pyrazol-5-yl)urea
• Synonyms: 1-(2-(2-chloropyrimidin-4-yloxy)-5-fluorobenzyl)-3-(3-t-butyl-1-p-tolyl-1 H-pyrazol-5-yl)urea
• CAS NO: 940870-53-1
• Molecular Weight: 508.983
• Mol File: 940870-53-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(2-(2-chloropyrimidin-4-yloxy)-5-fluorobenzyl)-3-(3-t-butyl-1-p-tolyl-1 H-pyrazol-5-yl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-(2-chloropyrimidin-4-yloxy)-5-fluorobenzyl)-3-(3-t-butyl-1-p-tolyl-1 H-pyrazol-5-yl)urea(940870-53-1)
• EPA Substance Registry System: 1-(2-(2-chloropyrimidin-4-yloxy)-5-fluorobenzyl)-3-(3-t-butyl-1-p-tolyl-1 H-pyrazol-5-yl)urea(940870-53-1)

Safety Data

• Hazardous Substances Data: 940870-53-1(Hazardous Substances Data)

Upstream product

• 3934-20-1 2,6-Dichloropyrimidine 
• 940875-04-7 1-(5-fluoro-2-hydroxybenzyl)-3-(3-t-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea 
• 317806-87-4 2,2,2-trichloroethyl 3-tert-butyl-1-p-tolyl-1H-pyrazol-5-ylcarbamate 

Downstream Products

• 940870-54-2 1-(2-(2-morpholinopyrimidin-4-yloxy)-5-fluorobenzyl)-3-(3-t-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea 
• 940871-46-5 (R)-1-(5-fluoro-2-(2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidin-4-yloxy)benzyl)-3-(3-t-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea 
• 940871-47-6 (S)-1-(5-fluoro-2-(2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidin-4-yloxy)benzyl)-3-(3-t-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea 
• 940871-48-7 (S)-methyl-1-(4-(2-((3-(3-t-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)methyl)-4-fluorophenoxy)pyrimidin-2-yl)pyrrolidin-2-carboxylate 
• 940871-21-6 1-(5-t-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-(5-fluoro-2-(2-(2-hydroxymethylmorpholin-4-yl)pyrimidin-4-yloxy)benzyl)urea 
• 940871-49-8 1-(5-fluoro-2-(2-(4-oxopiperidin-1-yl)pyrimidin-4-yloxy)benzyl)-3-(3-t-butyl-1-p-tolyl-1H-pyrazol-5-yl)urea 

Relevant articles and documents

Design and synthesis of novel p38α MAP kinase inhibitors: Discovery of pyrazole-benzyl ureas bearing 2-molpholinopyrimidine moiety

The discovery that pyrazole-benzyl urea derivatives bearing a 2-molpholinopyrimidine moiety are novel p38α inhibitors is described. A comparative view of the binding modes of SB-203580 and BIRB-796 by structural alignment of two X-ray co-crystal structures was utilized to identify this novel series. Modification of the benzyl group led to compound 2b, a highly potent p38α inhibitor. In in vivo studies, 2b inhibited the production of tumor necrosis factor-alpha in lipopolysaccharide-treated mouse in a dose-dependent manner. Furthermore, the results of a 5-day repeated oral dose toxicity study suggest that 2b has low hepatotoxicity.