940939-11-7Relevant articles and documents
Systematic Investigation of the Permeability of Androgen Receptor PROTACs
Scott, Duncan E.,Rooney, Timothy P. C.,Bayle, Elliott D.,Mirza, Tashfina,Willems, Henriette M. G.,Clarke, Jonathan H.,Andrews, Stephen P.,Skidmore, John
supporting information, p. 1539 - 1547 (2020/06/25)
Bifunctional molecules known as PROTACs simultaneously bind an E3 ligase and a protein of interest to direct ubiquitination and clearance of that protein, and they have emerged in the past decade as an exciting new paradigm in drug discovery. In order to investigate the permeability and properties of these large molecules, we synthesized two panels of PROTAC molecules, constructed from a range of protein-target ligands, linkers, and E3 ligase ligands. The androgen receptor, which is a well-studied protein in the PROTAC field was used as a model system. The physicochemical properties and permeability of PROTACs are discussed.
Molecular design and synthesis of fluorinated polyethers toward organic materials with high dielectric constants and ferroelectricity
Okano, Takashi,Hiraishi, Makiko,Mizutani, Tomonori
, p. 752 - 757 (2007/10/03)
Molecular design and synthesis of organic ferroelectric materials with a -OCH2CF2CH2O- moiety as the basic molecular structure were conducted in order to improve the high coercive field value of poly(vinylidene fluoride) (
