942273-38-3

Basic information

• Product Name: methyl 5-chloro-2-((trimethylsilyl)ethynyl)benzoate
• Synonyms: methyl 5-chloro-2-((trimethylsilyl)ethynyl)benzoate
• CAS NO: 942273-38-3
• Molecular Weight: 266.799
• Mol File: 942273-38-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: methyl 5-chloro-2-((trimethylsilyl)ethynyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 5-chloro-2-((trimethylsilyl)ethynyl)benzoate(942273-38-3)
• EPA Substance Registry System: methyl 5-chloro-2-((trimethylsilyl)ethynyl)benzoate(942273-38-3)

Safety Data

• Hazardous Substances Data: 942273-38-3(Hazardous Substances Data)

Upstream product

• 4068-78-4 methyl 5-chloro-2-hydroxybenzoate 
• 321-14-2 5-chloro-2-hydroxybenzoic acid 
• 1066-54-2 trimethylsilylacetylene 
• 494210-98-9 methyl 5-chloro-2-[((trifluoromethyl)sulfonyl)oxy]benzoate 
• 27007-53-0 methyl-2-bromo-5-chlorobenzoate 
• 13421-00-6 5-chloro-2-iodo-benzoic acid 
• 289039-82-3 methyl 5-chloro-2-iodo-benzoate 

Downstream Products

• 942273-26-9 methyl 5-chloro-2-ethynylbenzoate 
• 1403258-51-4 5-chloro-2-ethyl-3-[ethyl(oxan-4-yl)amino]benzoic acid 
• 1403258-50-3 methyl 5-chloro-2-ethyl-3-[(oxan-4-yl)amino]benzoate 
• 1403258-47-8 methyl 3-amino-5-chloro-2-ethylbenzoate 
• 1403258-46-7 methyl 5-chloro-2-ethyl-3-nitrobenzoate 
• 1310378-92-7 methyl 5-chloro-2-ethylbenzoate 
• 942273-39-4 C₂₄H₂₁Cl₂NO₄S 
• 942273-28-1 C₂₄H₁₇Cl₂NO₄S 
• 1403258-53-6 methyl 5-chloro-2-ethyl-3-[ethyl(oxan-4-yl)amino]benzoate 
• 1403596-44-0 5-chloro-2-ethyl-3-[methyl(oxan-4-yl)amino]benzoic acid 
• 1403596-43-9 methyl 5-chloro-2-ethyl-3-[methyl(oxan-4-yl)amino]benzoate 

Relevant articles and documents

Hydroiodination-Triggered Cascade Reaction with I2/PPh3/H2O: Metal-Free Access to 3-Substituted Phthalides from 2-Alkynylbenzoates

Phthalide is an important scaffold found in several biologically active compounds. Therefore, effective methods for the synthesis of phthalides are strongly desired. Herein, we describe the metal-free synthesis of 3-substituted phthalides by the reductive hydroiodination of 2-alkynylbenzoates through an I2/PPh3/H2O-triggered cascade reaction. A variety of 3-substituted phthalides were synthesized in excellent yields by a one-pot reaction involving four processes: desilylation, hydroiodination, cyclization, and reduction.

Intramolecular C-H activation through gold(I)-catalyzed reaction of iodoalkynes

The cycloisomerization reaction of 1-(iodoethynyl)-2-(1-methoxyalkyl)arenes and related 2-alkyl-substituted derivatives gives the corresponding 3-iodo-1-substituted-1H-indene under the catalytic influence of IPrAuNTf2 [IPr = 1,3-bis(2,6-diisopropyl)phenylimidazol-2-ylidene; NTf2 = bis(trifluoromethanesulfonyl)imidate]. The reaction takes place in 1,2-dichloroethane at 80°C, and the addition of ttbp (2,4,6-tritert-butylpyrimidine) is beneficial to accomplish this new transformation in high yield. The overall reaction implies initial assembly of an intermediate gold vinylidene upon alkyne activation by gold(I) and a 1,2-iodine-shift. Deuterium labeling and crossover experiments, the magnitude of the recorded kinetic primary isotopic effect, and the results obtained from the reaction of selected stereochemical probes strongly provide support for concerted insertion of the benzylic C-H bond into gold vinylidene as the step responsible for the formation of the new carbon-carbon bond.

Aryl- or Heteroaryl-Substituted Benzene Compounds

The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.