942475-01-6

Basic information

• Product Name: 2',4'-DIFLUORO-BIPHENYL-4-SULFONYL CHLORIDE
• Synonyms: 2',4'-DIFLUORO-BIPHENYL-4-SULFONYL CHLORIDE
• CAS NO: 942475-01-6
• Molecular Formula: C12H7ClF2O2S
• Molecular Weight: 288.7
• Mol File: 942475-01-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2',4'-DIFLUORO-BIPHENYL-4-SULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2',4'-DIFLUORO-BIPHENYL-4-SULFONYL CHLORIDE(942475-01-6)
• EPA Substance Registry System: 2',4'-DIFLUORO-BIPHENYL-4-SULFONYL CHLORIDE(942475-01-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 942475-01-6(Hazardous Substances Data)

Upstream product

• 1218794-17-2 2',4'-difluoro-[1,1'-biphenyl]-4-sulfonic acid 
• 37847-52-2 2,4-difluorobiphenyl 

Downstream Products

• 1218932-16-1 N-(3-cyanophenyl)-2',4'-difluorobiphenyl-4-sulfonamide 
• 1218932-10-5 2',4'-difluoro-N-(3-vinylphenyl)biphenyl-4-sulfonamide 
• 1218932-33-2 (R)-methyl 2-(tert-butoxycarbonylamino)-2-(3-(2',4'-difluorobiphenyl-4-ylsulfonamido)phenyl)acetate 
• 1218932-25-2 (R)-2',4'-difluoro-N-(3-(3-methyl-2-oxooxazolidin-4-yl)phenyl)biphenyl-4-sulfonamide 
• 1218932-53-6 methyl 2-(tert-butoxycarbonylamino)-2-(3-(2',4'-difluorobiphenyl-4-ylsulfonamido)phenyl)propanoate 
• 1218932-37-6 (S)-methyl 2-(tert-butoxycarbonylamino)-2-(3-(2',4'-difluorobiphenyl-4-ylsulfonamido)phenyl)acetate 
• 1609033-75-1 methyl 2-((4-(2′,4′-difluoro-[1,1′-biphenyl]-4-ylsulfonamido)-1-methoxynaphthalen-2-yl)thio)acetate 

Relevant articles and documents

N-ACYL-{4-[(4-ARYL-PHENYL)SULFONYLMETHYL]PIPERIDINE} COMPOUNDS AND THEIR THERAPEUTIC USE

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain N-acyl-{4-[(4-aryl- phenyl)sulfonylmethyl]piperidine} compounds of the following formula (collectively referred to

ARYL-PHENYL-SULFONAMIDO-CYCLOALKYL COMPOUNDS AND THEIR USE

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-cycloalkyl compounds of the following formula (collectively referred to herein as "APSAC compounds"). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in treatment, for example, of inflammation and/or joint destruction and/or bone loss; of disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; of inflammatory and autoimmune disorders, for example, rheumatoid arthritis, psoriasis, psoriatic arthritis, chronic obstructive pulmonary disease (COPD), atherosclerosis, inflammatory bowel disease, ankylosing spondylitis, and the like; of disorders associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, Paget's disease and the like, etc.; and of cancer, such as a haematological malignancy, a solid tumour, etc. Formula (I).