943-37-3

Basic information

• Product Name: ETHYL 5-NITRO-2-FUROATE
• Synonyms: RARECHEM AL BI 0008;ETHYL 5-NITRO-2-FUROATE;5-nitro-2-furoicaciethylester;5-Nitro-2-furancarboxylic acid ethyl ester;Ethyl 5-nitro-2-furoate,99%;Ethyl 5-nitrofuran-2-carboxylate
• CAS NO: 943-37-3
• Molecular Formula: C7H7NO5
• Molecular Weight: 185.13
• EINECS: 213-400-7
• Mol File: 943-37-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 98-101°C
• Boiling Point: 295.4°Cat760mmHg
• Flash Point: 132.4°C
• Appearance: /
• Density: 1.336g/cm³
• Vapor Pressure: 0.00153mmHg at 25°C
• Refractive Index: 1.511
• CAS DataBase Reference: ETHYL 5-NITRO-2-FUROATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 5-NITRO-2-FUROATE(943-37-3)
• EPA Substance Registry System: ETHYL 5-NITRO-2-FUROATE(943-37-3)

Safety Data

• Safety Statements: 22-24/25
• RTECS: LV2012500
• Hazardous Substances Data: 943-37-3(Hazardous Substances Data)

Usage

Chemical Properties

Yellow to orange flakes or crystalline powder

InChI:InChI=1/C7H7NO5/c1-2-12-7(9)5-3-4-6(13-5)8(10)11/h3-4H,2H2,1H3

Upstream product

• 645-12-5 5-nitro-2-furoic acid 
• 64-17-5 ethanol 
• 25084-14-4 5-nitrofuran-2-carboxylic chloride 
• 614-99-3 Ethyl 2-furoate 
• 5904-69-8 2-acetoxy-5-nitro-2,5-dihydro-furan-2-carboxylic acid ethyl ester 

Downstream Products

• 110-17-8 (2E)-but-2-enedioic acid 
• 1187383-36-3 ethyl 5-(2'-methoxycarbonyl-3'-methoxyphenoxy)furan-2-carboxylate 
• 123771-02-8 5-(2'-hydroxycarbonylphenoxy)furan-2-carboxylic acid 
• 123771-00-6 Ethyl 5-(2'-methoxycarbonylphenoxy)furan-2-carboxylate 
• 5469-78-3 5-nitrofuran-2-carbohydrazide 
• 720-69-4 6-(5-nitro-furan-2-yl)-[1,3,5]triazine-2,4-diamine 
• 15856-35-6 ethyl 2-amino-furan-5-carboxylate 

Relevant articles and documents

Graphene Oxide: An Efficient Acid Catalyst for the Construction of Esters from Acids and Alcohols

Graphene oxide was found to be an efficient and reusable acid catalyst for the esterification reaction. A wide range of aliphatic and aromatic acids and alcohols were compatible with the standard conditions and afforded the corresponding products in good yields. The heterogeneous catalyst can be easily recovered and recycled in dichloro-ethane solvent with good catalytic activity.

Rate-product correlations for the solvolysis of 5-nitro-2-furoyl chloride

The solvolysis rate constants of 5-nitro-2-furoyl chloride (5-NO 2(C4H2O)-2-COCl, 1) in 27 different solvents are well correlated with the extended Grunwald-Winstein equation, using the NT solvent nucleophilicity scale and YCl solvent ionizing scale, with sensitivity values of 1.20 ± 0.05 and 0.37 ± 0.02 for l and m, respectively. The activation enthalpies (ΔH≠) were 5.63 to 13.0 kcal·mol-1 and the activation entropies (ΔS ≠) were .25.9 to .43.4 cal·mol-1·K -1, which is consistent with the proposed bimolecular reaction mechanism. The solvent kinetic isotope effect (SKIE, kMeOH/kMeOD) of 2.65 was also in accord with the SN2 mechanism and was possibly assisted using a general-base catalysis. The product selectivity (S) for solvolysis of 1 in alcohol/water mixtures was 1.2 to 11, which is also consistent with the proposed bimolecular reaction mechanism.

QUINOLONE ANTIBACTERIAL AGENTS

Compounds of formula (I) and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula (I) as well as pharmaceutically acceptable compositions comprising compounds of formula (I). Compounds of formula (I) as disclosed herein can be used in a variety of applications including use as antibacterial agents.