943602-77-5

Basic information

• Product Name: 5-Amino-6-methylisoquinolin-1(2H)-one
• Synonyms: 5-Amino-6-methylisoquinolin-1(2H)-one
• CAS NO: 943602-77-5
• Molecular Formula: C10H10N2O
• Molecular Weight: 174.1992
• Mol File: 943602-77-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Amino-6-methylisoquinolin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Amino-6-methylisoquinolin-1(2H)-one(943602-77-5)
• EPA Substance Registry System: 5-Amino-6-methylisoquinolin-1(2H)-one(943602-77-5)

Safety Data

• Hazardous Substances Data: 943602-77-5(Hazardous Substances Data)

Usage

General Description

5-Amino-6-methylisoquinolin-1(2H)-one is an organic compound with the chemical formula C10H10N2O. It is a derivative of isoquinolinone, which is a bicyclic heteroaromatic compound. This chemical is used in the synthesis of various pharmaceuticals and organic compounds, particularly in the field of medicinal chemistry. Its structure contains an amino group and a methyl group, making it a versatile building block for the construction of more complex molecules. Additionally, its isoquinolinone core provides a unique structural scaffold for the development of novel drugs and biologically active compounds. Overall, 5-Amino-6-methylisoquinolin-1(2H)-one is an important intermediate in the synthesis of diverse chemical compounds with potential applications in the pharmaceutical and medical industries.

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 943606-83-5 6-methyl-5-nitroisoquinoline N-oxide 
• 943606-84-6 1-chloro-6-methyl-5-nitroisoquinoline 
• 42398-73-2 6-methylisoquinoline 
• 188121-31-5 6-methyl-5-nitroisoquinoline 
• 943606-85-7 6-methyl-5-nitroisoquinolin-1(2H)-one 

Downstream Products

• 1093101-59-7 5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-1-chloro-6-methylisoquinoline 
• 1093100-24-3 5-(3-(9H-purin-6-yl)pyridin-2-yloxy)-N-(4-chlorophenyl)-6-methylisoquinolin-1-amine 
• 1093101-58-6 5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-6-methylisoquinolin-1(2H)-one 
• 1093101-60-0 5-(3-(9-(4-methoxybenzyl)-9H-purin-6-yl)pyridin-2-yloxy)-N-(4-chlorophenyl)-6-methylisoquinolin-1-amine 

Relevant articles and documents

Selective inhibitors of the mutant B-Raf pathway: Discovery of a potent and orally bioavailable aminoisoquinoline

The discovery and optimization of a novel series of aminoisoquinolines as potent, selective, and efficacious inhibitors of the mutant B-Raf pathway is presented. The N-linked pyridylpyrimidine benzamide 2 was identified as a potent, modestly selective inhibitor of the B-Raf enzyme. Replacement of the benzamide with an aminoisoquinoline core significantly improved kinase selectivity and imparted favorable pharmacokinetic properties, leading to the identification of 1 as a potent antitumor agent in xenograft models. 2009 American Chemical Society.

NITROGEN-CONTAINING BICYCLIC HETEROARYL COMPOUNDS AND METHODS OF USE

The present invention comprises a new class of compounds capable of modulating Raf kinase and, accordingly, useful for treatment of Raf kinase mediated diseases, including melanomas, tumors and other cancer-related conditions. The compounds have Formula (I) wherein R1 is Formula (II), (III) or (IV) and A1, A2, A3, A4, X, Z, Z', R1, R2, R3, R4, R5 and R6 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of Raf kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.