943605-97-8

Basic information

• Product Name: 6-(2-fluoropyridin-3-yl)-Nmethylpyrimidin-4-amine
• Synonyms: 6-(2-fluoropyridin-3-yl)-Nmethylpyrimidin-4-amine
• CAS NO: 943605-97-8
• Molecular Formula: C₁₀H₉FN₄
• Molecular Weight: 204.207
• Mol File: 943605-97-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 408.4°C at 760 mmHg
• Flash Point: 200.8°C
• Appearance: /
• Density: 1.291g/cm³
• Vapor Pressure: 7E-07mmHg at 25°C
• Refractive Index: 1.608
• CAS DataBase Reference: 6-(2-fluoropyridin-3-yl)-Nmethylpyrimidin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(2-fluoropyridin-3-yl)-Nmethylpyrimidin-4-amine(943605-97-8)
• EPA Substance Registry System: 6-(2-fluoropyridin-3-yl)-Nmethylpyrimidin-4-amine(943605-97-8)

Safety Data

• Hazardous Substances Data: 943605-97-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H9FN4/c1-12-9-5-8(14-6-15-9)7-3-2-4-13-10(7)11/h2-6H,1H3,(H,12,14,15)

Upstream product

• 65766-32-7 6-chloro-N-methylpyrimidin-4-amine 
• 174669-73-9 (2-fluoro-pyridin-3-yl)boronic acid 

Relevant articles and documents

NITROGEN-CONTAINING BICYCLIC HETEROARYL COMPOUNDS AND METHODS OF USE

The present invention comprises a new class of compounds capable of modulating Raf kinase and, accordingly, useful for treatment of Raf kinase mediated diseases, including melanomas, tumors and other cancer-related conditions. The compounds have Formula (I) wherein R1 is Formula (II), (III) or (IV) and A1, A2, A3, A4, X, Z, Z', R1, R2, R3, R4, R5 and R6 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of Raf kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.