94427-27-7Relevant articles and documents
Synthesis and Dihydropteridine Reductase Inhibitory Effects of Potential Metabolites of the Neurotoxin 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Gessner, Wieslaw,Brossi, Arnold,Shen, Rong-sen,Abell, Creed W.
, p. 311 - 317 (2007/10/02)
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a nigrostriatal neurotoxin which can cause irreversible parkinsonism in humans and primates by selective destruction of neurons in the substantia nigra.It is possible that MPTP could be metabolized by