944282-79-5

Basic information

• Product Name: (1R,2S,3S,5S)-5-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxyphenyl]methyl]-3-ethenyl-2-(1-methylene-2-propen-1-yl)cyclopentenecarboxaldehyde
• CAS NO: 944282-79-5
• Molecular Weight: 426.671
• Mol File: 944282-79-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,2S,3S,5S)-5-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxyphenyl]methyl]-3-ethenyl-2-(1-methylene-2-propen-1-yl)cyclopentenecarboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S,3S,5S)-5-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxyphenyl]methyl]-3-ethenyl-2-(1-methylene-2-propen-1-yl)cyclopentenecarboxaldehyde(944282-79-5)
• EPA Substance Registry System: (1R,2S,3S,5S)-5-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxyphenyl]methyl]-3-ethenyl-2-(1-methylene-2-propen-1-yl)cyclopentenecarboxaldehyde(944282-79-5)

Safety Data

• Hazardous Substances Data: 944282-79-5(Hazardous Substances Data)

Upstream product

• 944282-78-4 (3S,5S)-5-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxyphenyl]methyl]-3-ethenyl-1-cyclopentene-1-carboxaldehyde 
• 126-99-8 chloroprene 

Relevant articles and documents

Synthesis of the potent anticancer agents ottelione A and ottelione B in both racemic and natural optically pure forms

(Chemical Equation Presented) The powerful antitumor agents ottelione A and B were synthesized in racemic form by a method that relies on selective ring closing metathesis. Optically pure natural (+)-ottelione A was then made from D-ribose, via an α-keto cyclopropane. A key feature of the route is that the cyclopropyl group controls the stereochemistry in the attachment of the ArCH2 unit and is then converted by the action of SmI2 into a vinyl group, so that the substituents on the resulting five-membered ring have the required trans relationship. Epimerization of an intermediate gave access by the same method to the trans ring fused isomer (-)-ottelione B.