944401-65-4

Basic information

• Product Name: 5-bromo-6-fluoropyridin-2-amine
• Synonyms: 5-bromo-6-fluoropyridin-2-amine;5-Bromo-6-fluoropyridin-2-ylamine;6-AMino-3-broMo-2-fluoropyridine
• CAS NO: 944401-65-4
• Molecular Formula: C₅H₄BrFN₂
• Molecular Weight: 191.0010632
• Mol File: 944401-65-4.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 245℃
• Flash Point: 102℃
• Appearance: /
• Density: 1.813
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 1.25±0.10(Predicted)
• CAS DataBase Reference: 5-bromo-6-fluoropyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-6-fluoropyridin-2-amine(944401-65-4)
• EPA Substance Registry System: 5-bromo-6-fluoropyridin-2-amine(944401-65-4)

Safety Data

• Hazardous Substances Data: 944401-65-4(Hazardous Substances Data)

Usage

Description

5-bromo-6-fluoropyridin-2-amine is an organic intermediate with a unique structure featuring a pyridine ring substituted with a bromine at the 5th position and a fluorine at the 6th position, along with an amine group at the 2nd position. 5-bromo-6-fluoropyridin-2-amine is synthesized through the bromination of 6-fluoropyridin-2-amine, a process that introduces a bromine atom to the molecule, enhancing its reactivity and potential applications in various chemical and pharmaceutical processes.

Uses

Used in Pharmaceutical Industry:
5-bromo-6-fluoropyridin-2-amine is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a versatile building block for the development of new drugs, particularly those targeting specific biological pathways or receptors. The presence of the bromine and fluorine atoms, along with the amine group, enables the formation of diverse chemical bonds and interactions, making it a valuable component in the creation of novel therapeutic agents.
Used in Chemical Synthesis:
In the field of chemical synthesis, 5-bromo-6-fluoropyridin-2-amine serves as a valuable intermediate for the production of a wide range of organic compounds. Its reactivity and structural features make it suitable for use in various organic reactions, such as cross-coupling, substitution, and condensation reactions. This allows chemists to create new molecules with specific properties and applications, including those in materials science, agrochemicals, and specialty chemicals.
Used in Research and Development:
5-bromo-6-fluoropyridin-2-amine is also utilized in research and development settings, where it can be employed to study the effects of structural modifications on the properties and reactivity of pyridine-based compounds. Researchers can use this intermediate to explore new synthetic routes, investigate the influence of halogen atoms on molecular properties, and develop new methodologies for the synthesis of complex organic molecules.

Upstream product

• 80392-79-6 3-bromo-2,6-difluoro-pyridine 
• 1597-32-6 6-fluoro-pyridin-2-ylamine 

Downstream Products

• 944401-67-6 6-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine 
• 1267852-21-0 6-fluoro-5-(4-(2-oxo-2-(5-(1-(trifluoromethyl)cyclopropyl)isoxazol-3-ylamino)ethyl)phenyl)pyridin-2-amine 

Relevant articles and documents

alpha-SYNUCLEIN AGGREGATE BINDING AGENT AND IMAGING METHOD

The present invention provides an α-synuclein aggregate binding agent that has high binding selectivity for an α-synuclein aggregate. The α-synuclein aggregate binding agent contains a compound represented by a formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof: in the formula (I), R1 and R2 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R3 is hydrogen or halogen; the ring A is a benzene or pyridine ring; the ring B is represented by the following formula (i) or (ii): R4 and R5 are each independently selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl.

1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES AS BCL-2 INHIBITORS FOR THE TREATMENT OF NEOPLASTIC AND AUTOIMMUNE DISEASES

The present invention relates to lH-pyrrolo[2,3-b]pyridine derivatives and related compounds as BCL-2 inhibitors for treating neoplastic, autoimmune or neurodegenerative diseases. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 162 to 233; examples 1 to 8; table; compound examples cpd-1 to cpd-135; biological examples 1 to 4).

TYK2 INHIBITORS AND USES THEREOF

Described herein are compounds that are useful in treating a TYK2-mediated disorder. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a disorder associated with transplantation.