944475-10-9

Basic information

• Product Name: 2,5-ANHYDRO-1-AZIDO-1,3-DIDEOXY-3-(3,4-DIHYDRO-5-METHYL-2,4-DIOXO-1(2H)-PYRIMIDINYL)-L-MANNITOL
• Synonyms: 2,5-ANHYDRO-1-AZIDO-1,3-DIDEOXY-3-(3,4-DIHYDRO-5-METHYL-2,4-DIOXO-1(2H)-PYRIMIDINYL)-L-MANNITOL
• CAS NO: 944475-10-9
• Molecular Formula: C11H15N5O5
• Molecular Weight: 297.27
• Mol File: 944475-10-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,5-ANHYDRO-1-AZIDO-1,3-DIDEOXY-3-(3,4-DIHYDRO-5-METHYL-2,4-DIOXO-1(2H)-PYRIMIDINYL)-L-MANNITOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-ANHYDRO-1-AZIDO-1,3-DIDEOXY-3-(3,4-DIHYDRO-5-METHYL-2,4-DIOXO-1(2H)-PYRIMIDINYL)-L-MANNITOL(944475-10-9)
• EPA Substance Registry System: 2,5-ANHYDRO-1-AZIDO-1,3-DIDEOXY-3-(3,4-DIHYDRO-5-METHYL-2,4-DIOXO-1(2H)-PYRIMIDINYL)-L-MANNITOL(944475-10-9)

Safety Data

• Hazardous Substances Data: 944475-10-9(Hazardous Substances Data)

Usage

Molecular structure

2,5-anhydro ring, azido group, dideoxy sugar, 3-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl) group, L-mannitol core.

Functional groups

Azido (N3), dideoxy sugar (lacking two oxygen atoms), pyrimidinyl moiety (a heterocyclic aromatic ring).

Molecular weight

267.22 g/mol (calculated from the molecular formula).

Potential applications

Pharmaceutical agent (due to the presence of azido, dideoxy, and pyrimidinyl groups).

Research status

Further research needed to understand its properties and potential applications (as mentioned in the material provided).

Relevant articles and documents

Studies on modified oligonucleotides

A series of isonucleotide incorporated antisense oligodeoxynucleotides have been synthesized, in which isonucleotide was introduced at different positions of the sequences. The results showed that though the incorporated isonucleotides at different position of the sequence interfered in the binding ability in different extent, B-form duplexes were maintained and the binding abilities of the 3′-end modified duplexes were better than the corresponding mismatched duplexes. The DNA/RNA hybrid formed by modified oligodeoxynucleotide and its target RNA could activate the activity of RNase H. The 3′-end modified antisense oligodeoxynucelotides showed the inhibition on S glycoprotein expression of SARS-CoV at the mRNA levels in insect Sf9 cells. In this presentation, a novel class of amino-isonucleoside was synthesized and incorporated into different positions in the sense or antisense strand of siRNA duplexes. The 3′ and 5′ sense strand aminonucleoside modified siRNAs (ssISO-siRNA1 and ssISO-siRNA2) showed the similar duplex thermal and serum stability as natural one and the luciferase activities showed that such modified siRNA is compatible with the intracellular siRNA machinery. Copyright Taylor & Francis Group, LLC.