944482-71-7

Basic information

• Product Name: C₂₃H₂₀ClFN₄O₃
• CAS NO: 944482-71-7
• Molecular Weight: 454.888
• Mol File: 944482-71-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₀ClFN₄O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₀ClFN₄O₃(944482-71-7)
• EPA Substance Registry System: C₂₃H₂₀ClFN₄O₃(944482-71-7)

Safety Data

• Hazardous Substances Data: 944482-71-7(Hazardous Substances Data)

Upstream product

• 944482-65-9 C₁₀H₁₀ClN₃O₂ 
• 202197-26-0 3-chloro-4-(3-fluorobenzyloxy)aniline 

Downstream Products

• 944482-72-8 4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-3-methyl-1H-pyrrolo[2,3-d]-pyridazine-2-carboxylic acid 

Relevant articles and documents

Synthesis and biological evaluation of pyrrolopyridazine derivatives as novel HER-2 tyrosine kinase inhibitors

A series of novel pyrrolopyridazine derivatives have been discovered to be HER-2 inhibitors. These compounds selectively inhibited HER-2 kinase activity at low nanomolar concentrations. Compound 7d was identified as a potent HER-2 inhibitor with an IC50 of 4 nM.