944914-05-0

Basic information

• Product Name: (4S,5S)-4-(2-hydroxyethyl)-5-(1-methylethyl)-1-phenylmethyl-imidazolidin-2-one
• Synonyms: (4S,5S)-4-(2-hydroxyethyl)-5-(1-methylethyl)-1-phenylmethyl-imidazolidin-2-one
• CAS NO: 944914-05-0
• Molecular Weight: 262.352
• Mol File: 944914-05-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (4S,5S)-4-(2-hydroxyethyl)-5-(1-methylethyl)-1-phenylmethyl-imidazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4S,5S)-4-(2-hydroxyethyl)-5-(1-methylethyl)-1-phenylmethyl-imidazolidin-2-one(944914-05-0)
• EPA Substance Registry System: (4S,5S)-4-(2-hydroxyethyl)-5-(1-methylethyl)-1-phenylmethyl-imidazolidin-2-one(944914-05-0)

Safety Data

• Hazardous Substances Data: 944914-05-0(Hazardous Substances Data)

Upstream product

• 944913-91-1 (S)-1-benzyl-4-[(Z)-tert-butyloxycarbonylmethylidene]-5-(1-methylethyl)-imidazolidin-2-one 
• 17343-55-4 (S)-N-benzyloxycarbonyl-2-amino-isopentanenitrile 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 13139-28-1 (S)-N-benzyloxycarbonylvalinamide 
• 72-18-4 L-valine 
• 944913-87-5 (S)-2-(N-benzyl-N-benzyloxycarbonylamino)-isopentanonitrile 

Relevant articles and documents

AmIno Acid Homologation by the Blaise Reaction: A new entry into nitrogen heterocycles

(Chemical Equation Presented) A general strategy for the amino acid homologation via Blaise reaction and subsequent reduction is presented. This strategy involves the preparation of protected α-amino nitriles from the corresponding amino acids, followed by the zinc-mediated condensation of tert-butyl bromoacetate, to give the imidazolidones after iminozincate cyclization. Reduction gave the saturated imidazolidinones with cis or trans stereochemistry, depending on the reduction conditions. This strategy was applied to nonfunctionalized amino acids and to functionalized amino acids such as serine and aspartic acid. Additionally, acidic hydrolysis of cis or trans imidazolidinones to the corresponding chiral 4-aminopyrrolidones is described.