945217-60-7

Basic information

• Product Name: (3R,4S)-rel-1-Boc--3,4-diaMinopyrrolidine
• Synonyms: (3R,4S)-rel-1-Boc--3,4-diaMinopyrrolidine;(3R,4S)-rel-tert-Butyl 3,4-diaminopyrrolidine-1-carboxylate;tert-butyl cis-3,4-diaminopyrrolidine-1-carboxylate;Cis-N-BOC-3,4-diaminopyrrolidine;cis tert-Butyl 3,4-diaminopyrrolidine-1-carboxylate;CIS-1-BOC-3,4-DIAMINOPYRROLIDINE;tert-Butyl (3S,4R)-3,4-diaminopyrrolidine-1-carboxylate
• CAS NO: 945217-60-7
• Molecular Formula: C₉H₁₉N₃O₂
• Molecular Weight: 201.27
• Mol File: 945217-60-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 292.2±40.0 °C(Predicted)
• Appearance: /
• Density: 1.105±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.45±0.40(Predicted)
• CAS DataBase Reference: (3R,4S)-rel-1-Boc--3,4-diaMinopyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4S)-rel-1-Boc--3,4-diaMinopyrrolidine(945217-60-7)
• EPA Substance Registry System: (3R,4S)-rel-1-Boc--3,4-diaMinopyrrolidine(945217-60-7)

Safety Data

• Hazardous Substances Data: 945217-60-7(Hazardous Substances Data)

Usage

General Description

The chemical (3R,4S)-rel-1-Boc-3,4-diaMinopyrrolidine is a compound with a specific stereochemical configuration, indicated by the 3R and 4S designations. It is a pyrrolidine derivative with a Boc (tert-butyloxycarbonyl) protecting group attached to the amine group at the 1-position. Pyrrolidines are heterocyclic compounds containing a five-membered ring with one nitrogen atom, and they are commonly found in various natural products and pharmaceuticals. The Boc protecting group is often used to temporarily mask reactive functionalities while chemical reactions take place elsewhere in the molecule. Overall, the chemical (3R,4S)-rel-1-Boc-3,4-diaMinopyrrolidine is a specific compound with potential applications in organic synthesis and pharmaceutical research.

Upstream product

• 4248-19-5 tert-butyl carbazate 
• 186393-22-6 rac-tert-butyl (3R,4S)-3,4-dihydroxypyrrolidine-1-carboxylate 
• 190792-84-8 (3S,4S)-3-azido-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 114214-49-2 1-tert-butoxycarbonyl-3,4-epoxypyrrolidine 
• 73286-70-1 N-(tert-butoxycarbonyl)-3-pyrroline 
• 1202067-33-1 (3S,4S)-3-azido-4-(trimethylsilanyloxy)pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1202067-51-3 (3S,4S)-3-azido-4-(methanesulfonyloxy)pyrrolidine-1-carboxylic acid tert-butyl ester 
• 945217-59-4 tert-butyl (3S,4R)-3,4-diazidopyrrolidine-1-carboxylate 

Downstream Products

• 1202067-74-0 cis-(3,6)-2-phenyl-3a,4,6,6a-tetrahydro-1H-pyrrolo[3,4-d]imidazole-5-carboxylic acid tert-butyl ester 

Relevant articles and documents

Discovery of 1-pyrimidinyl-2-aryl-4,6-dihydropyrrolo [3,4-d]imidazole-5(1H)-carboxamide as a novel JNK inhibitor

We designed and synthesized 1-pyrimidinyl-2-aryl-4, 6-dihydropyrrolo [3,4-d] imidazole-5(1H)-carboxamide derivatives as selective inhibitors of c-Jun-N-terminal Kinase 3 (JNK3), a target for the treatment of neurodegenerative diseases. Based on the compounds found in previous studies, a novel scaffold was designed to improve pharmacokinetic characters and activity, and compound 18a, (R)-1-(2-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)amino)pyrimidin-4-yl)-2-(3,4-dichlorophenyl)-4,6-dihydro pyrrolo [3,4-d]imidazole-5(1H)-carboxamide, showed the highest IC50 value of 2.69 nM. Kinase profiling results also showed high selectivity for JNK3 among 38 kinases, having mild activity against JNK2, RIPK3, and GSK3β, which also known to involve in neuronal apoptosis.