945761-95-5

Basic information

• Product Name: 3-bromo-7-nitro-2H-indazole
• Synonyms: 1H-Indazole, 3-bromo-7-nitro-; 3-Bromo-7-nitro-1H-indazole; 3-bromo-7-iodo-2H-indazole
• CAS NO: 945761-95-5
• Molecular Formula: C₇H₄BrIN₂
• Molecular Weight: 322.9285
• Mol File: 945761-95-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 242.9°C at 760 mmHg
• Flash Point: 100.7°C
• Density: 2.421g/cm³
• Vapor Pressure: 0.033mmHg at 25°C
• Refractive Index: 1.804
• CAS DataBase Reference: 3-bromo-7-nitro-2H-indazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-7-nitro-2H-indazole(945761-95-5)
• EPA Substance Registry System: 3-bromo-7-nitro-2H-indazole(945761-95-5)

Safety Data

• Hazardous Substances Data: 945761-95-5(Hazardous Substances Data)

Usage

General Description

3-bromo-7-nitro-2H-indazole is a chemical compound with the molecular formula C7H4BrN3O2. It is a nitro-substituted indazole derivative, which is commonly used as a building block in pharmaceutical research and synthesis. 3-bromo-7-nitro-2H-indazole is a yellow solid with a melting point of 269-271°C and is typically stored and handled under strict laboratory conditions due to its potential hazards. 3-bromo-7-nitro-2H-indazole has been studied for its potential pharmacological properties and is of interest for its potential biological activities. Its precise applications may vary, but it has been reported in scientific literature as a precursor in the synthesis of various biologically active compounds in medicinal chemistry.

Upstream product

• 2942-42-9 7-Nitroindazole 
• 21443-96-9 1H-indazol-7-amine 
• 570-24-1 2-Methyl-6-nitroaniline 
• 945761-94-4 7-iodo-1H-indazole 

Downstream Products

• 945762-00-5 3-bromo-7-cyano-1H-indazole 

Relevant articles and documents

Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: Particular potency of 1H-indazole-7-carbonitrile

A series of new 7-monosubstituted and 3,7-disubstituted indazoles have been prepared and evaluated as inhibitors of nitric oxide synthases (NOS). 1H-Indazole-7-carbonitrile (6) was found equipotent to 7-nitro-1H-indazole (1) and demonstrated preference for constitutive NOS over inducible NOS. By contrast, 1H-indazole-7-carboxamide (8) was slightly less potent but demonstrated a surprising selectivity for the neuronal NOS. Further substitution of 6 by a Br-atom at carbon-3 of the heterocycle enhanced 10-fold the inhibitory effects. Inhibition of NO formation by 6 appeared to be competitive versus both substrate and the cofactor (6R)-5,6,7,8-tetrahydro-l-biopterin (H4B). In close analogies with 1, compound 6 strongly inhibited the NADPH oxidase activity of nNOS and induced a spin state transition of the heme-FeIII. Our results are explained with the help of the X-ray structures that identified key-features for binding of 1 at the active site of NOS.