946000-58-4

Basic information

• Product Name: methanesulfonic acid 2-[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-phenyl]-ethyl ester
• Synonyms: methanesulfonic acid 2-[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-phenyl]-ethyl ester
• CAS NO: 946000-58-4
• Molecular Weight: 378.992
• Mol File: 946000-58-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methanesulfonic acid 2-[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-phenyl]-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: methanesulfonic acid 2-[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-phenyl]-ethyl ester(946000-58-4)
• EPA Substance Registry System: methanesulfonic acid 2-[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-phenyl]-ethyl ester(946000-58-4)

Safety Data

• Hazardous Substances Data: 946000-58-4(Hazardous Substances Data)

Upstream product

• 149965-40-2 5-bromo-2-chlorobenzyl alcohol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 946000-54-0 tert-butyl-(2-chloro-5-vinyl-benzyloxy)-dimethyl-silane 
• 873782-26-4 ((5-bromo-2-chlorobenzyl)oxy)(tert-butyl)dimethylsilane 
• 946000-56-2 2-[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-phenyl]-ethanol 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 946001-33-8 {2-[3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-chloro-phenyl]-ethyl}-(2,2-difluoro-ethyl)carbamic Acid tert-butyl Ester 
• 946000-62-0 {2-[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-phenyl]-ethyl}-cyclopropyl-carbamic acid tert-butyl ester 
• 946001-38-3 [2-(4-Chloro-3-cyclopropylaminomethyl-phenyl)ethyl]-(2,2-difluoro-ethyl)-carbamic Acid tert-butyl Ester 
• 946000-68-6 [2-(4-chloro-3-cyclopropylaminomethyl-phenyl)-ethyl]-cyclopropyl-carbamic acid tert-butyl ester 
• 946001-34-9 [2-(4-chloro-3-hydroxymethyl-phenyl)-ethyl]-(2,2-difluoro-ethyl)-carbamic acid tert-butyl ester 
• 946000-64-2 [2-(4-chloro-3-hydroxymethyl-phenyl)-ethyl]-cyclopropyl-carbamic acid tert-butyl ester 
• 946001-36-1 [2-(4-Chloro-3-formyl-phenyl)ethyl]-(2,2-difluoro-ethyl)carbamic Acid tert-butyl Ester 
• 946000-66-4 [2-(4-chloro-3-formyl-phenyl)-ethyl]-cyclopropyl-carbamic acid tert-butyl ester 
• 946000-60-8 {2-[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-chloro-phenyl]-ethyl}-cyclopropyl-amine 

Relevant articles and documents

Secondary Amines as Renin Inhibitors

The invention relates to novel secondary amine derivatives of formula (I) and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.

SECONDARY AMINES AS RENIN INHIBITORS

The invention relates to novel secondary amine derivatives of formula (I) and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.