94644-47-0

Basic information

• Product Name: 2-CHLORO-6,7-DIMETHOXYQUINAZOLINE
• Synonyms: 2-CHLORO-6,7-DIMETHOXYQUINAZOLINE;Quinazoline, 2-chloro-6,7-diMethoxy-
• CAS NO: 94644-47-0
• Molecular Formula: C₁₀H₉ClN₂O₂
• Molecular Weight: 224.64
• Mol File: 94644-47-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 320°C at 760 mmHg
• Flash Point: 147.3°C
• Appearance: /
• Density: 1.321g/cm³
• Vapor Pressure: 0.000613mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: 2-8°C
• PKA: 0.16±0.30(Predicted)
• CAS DataBase Reference: 2-CHLORO-6,7-DIMETHOXYQUINAZOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-6,7-DIMETHOXYQUINAZOLINE(94644-47-0)
• EPA Substance Registry System: 2-CHLORO-6,7-DIMETHOXYQUINAZOLINE(94644-47-0)

Safety Data

• Hazardous Substances Data: 94644-47-0(Hazardous Substances Data)

Usage

General Description

2-CHLORO-6,7-DIMETHOXYQUINAZOLINE is an organic compound with the molecular formula C10H10ClN3O2. It is a quinazoline derivative with two methoxy groups and a chlorine atom attached to the quinazoline ring. This chemical is commonly used in the synthesis of pharmaceuticals and agrochemicals. It has been studied for its potential antitumor and antimalarial activities. 2-CHLORO-6,7-DIMETHOXYQUINAZOLINE is also known for its potential as a building block for various biologically active compounds. Its versatile chemical structure and potential biological activities make it a valuable compound for medicinal and agricultural applications.

InChI:InChI=1/C10H9ClN2O2/c1-14-8-3-6-5-12-10(11)13-7(6)4-9(8)15-2/h3-5H,1-2H3

Upstream product

• 27631-29-4 2-chloro-6,7-dimethoxy-3H-quinazolin-4-one 

Downstream Products

• 1036743-33-5 4-(6,7-dimethoxyquinazolin-2-ylamino)benzenesulfonamide 
• 253191-99-0 4-[1-(6,7-Dimethoxyquinazolin-2-yl)piperidin-4-ylamino]benzoic acid tert-butyl ester 

Relevant articles and documents

Search for the pharmacophore in prazosin for Transport-P

Partial structures of prazosin have been synthesised and tested for inhibition of Transport-P in order to identify the structural features of prazosin, which appear to be involved in binding to the putative transporter. It is shown that the pyrimidinyl 4-amino group is critically important for binding but that the 6,7-dimethoxy and 2-furoyl groups are not essential.

Structure-activity relationships of novel 2-substituted quinazoline antibacterial agents

High-throughput screening of in-house compound libraries led to the discovery of a novel antibacterial agent, compound 1 (MIC: 12-25 μM against S. pyogenes). In an effort to improve the activity of this active compound, a series of 2-substituted quinazolines was synthesized and evaluated in several antibacterial assays. One such compound (22) displayed improved broad- spectrum antibacterial activity against a variety of bacterial strains. This molecule also inhibited transcription/translation of bacterial RNA, suggesting a mechanism for its antibiotic effects. Structure-activity relationship studies of 22 led to the synthesis of another 24 compounds. Although some of these molecules were found to be active in bacterial growth assays, none were as potent as 22. Compound 22 was tested for its ability to cure a systemic K. pneumonia infection in the mouse and displayed moderate effects compared with a control antibiotic, gentamycin.