946870-92-4

Basic information

• Product Name: IGF-1 LR3
• Synonyms: IGF-1 LR3;CL281
• CAS NO: 946870-92-4
• Mol File: 946870-92-4.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: IGF-1 LR3(CAS DataBase Reference)
• NIST Chemistry Reference: IGF-1 LR3(946870-92-4)
• EPA Substance Registry System: IGF-1 LR3(946870-92-4)

Safety Data

• Hazardous Substances Data: 946870-92-4(Hazardous Substances Data)

Usage

Description

IGF-1 LR3, also known as Long R3-IGF-1, is a synthetic protein and an extended analogue of human insulin-like growth factor 1 (IGF-1). It is distinguished from the native IGF-1 by having an arginine instead of a glutamic acid at the third position in its amino acid sequence ("arginine 3") and an additional 13 amino acids at its N-terminus (MFPAMPLLSLFVN) ("long"), totaling 83 amino acids (compared to the 70 of IGF-1). These modifications endow IGF-1 LR3 with the pharmacological activity of IGF-1 as an agonist of the IGF-1 receptor, very low affinity for insulin-like growth factor-binding proteins (IGFBPs), and improved metabolic stability. Consequently, it is approximately three times more potent than IGF-1 and has a significantly longer half-life of about 20–30 hours (compared to IGF-1's half-life of about 12–15 hours).

Uses

Used in Pharmaceutical Industry:
IGF-1 LR3 is used as a therapeutic agent for promoting cell growth and development due to its enhanced potency and longer half-life compared to native IGF-1. Its low affinity for IGFBPs allows for more effective interaction with the IGF-1 receptor, making it a promising candidate for the treatment of conditions that involve impaired cell growth or tissue repair.
Used in Anti-Aging and Regenerative Medicine:
IGF-1 LR3 is used as an anti-aging and regenerative medicine agent to promote tissue repair, enhance muscle growth, and improve overall cellular health. Its increased potency and longer half-life make it an attractive option for addressing age-related decline in cellular function and promoting the rejuvenation of tissues.
Used in Sports and Performance Enhancement:
IGF-1 LR3 is used as a performance-enhancing substance by athletes and bodybuilders to stimulate muscle growth, increase strength, and enhance recovery from exercise-induced muscle damage. Its ability to promote cell growth and repair makes it a popular choice for those seeking to improve their physical performance and appearance.
Used in Research Applications:
IGF-1 LR3 is used as a research tool in biological and medical studies to investigate the role of IGF-1 in various physiological processes, such as cell growth, differentiation, and apoptosis. Its modified properties allow researchers to study the effects of IGF-1 with greater precision and control, leading to a better understanding of its mechanisms of action and potential therapeutic applications.

Mechanism of action

IGF-1 LR3 binds to cell receptors in the muscle cells and activates cell communication, which then improves the growth rate of muscles.IGF-1 LR3 obstructs the movement of glucose into the body’s cells. This facilitates fat burning and the use of fat in the body for the production of energy. IGF-1 LR3 has a life in the body for about 20-30 hours and therefore enhance the growth amount of muscle for a whole day.

Side effects

Some possible side effects of IGF-1 LR3 may include the following: muscle and joint pain, nausea, headaches, hypoglycemia (usually when IGF-1 LR3 is administered in continuous high doses) and may be associated with increased risk of developing some cancers.