94695-48-4

Basic information

• Product Name: 2,3,4,5-Tetrafluorobenzoyl chloride
• Synonyms: 2,3,4,5-TETRAFLUORBENZOYLCHLORID;2,3,4,5-TETRAFLUOROBENZOYL CHLORIDE;Benzoyl chloride, 2,3,4,5-tetrafluoro- (9CI);2,3,4,5-Tetrafluorobenzoyl;2,3,4,5-Tetrafluorobenzoyl chloride 98%;2,3,4,5-TETRAFLUOROBEZOYL CHLORIDE;2,3,4,5-Tetrafluorobenzoylchloride98%;2,3,4,5-Tetrafluorobenzoic acid chloride
• CAS NO: 94695-48-4
• Molecular Formula: C₇HClF₄O
• Molecular Weight: 212.53
• EINECS: -0
• Product Categories: ACIDHALIDE;Miscellaneous;API intermediates;Acid Halides;Carbonyl Compounds;Organic Building Blocks
• Mol File: 94695-48-4.mol
• Article Data: 33

Chemical Properties

• Boiling Point: 65-66°C 10mm
• Flash Point: 194 °F
• Appearance: clear colorless liquid
• Density: 1.58 g/mL at 25 °C(lit.)
• Vapor Pressure: 1.21mmHg at 25°C
• Refractive Index: n20/D 1.4787(lit.)
• Sensitive: Moisture Sensitive
• BRN: 5266860
• CAS DataBase Reference: 2,3,4,5-Tetrafluorobenzoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4,5-Tetrafluorobenzoyl chloride(94695-48-4)
• EPA Substance Registry System: 2,3,4,5-Tetrafluorobenzoyl chloride(94695-48-4)

Safety Data

• Hazard Codes: C
• Statements: 34-37-36/37
• Safety Statements: 26-36/37/39-45-25
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• F: 10-19-21
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 94695-48-4(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless liquid

Uses

2,3,4,5-Tetrafluorobenzoyl chloride was used in the preparation of 4-hydroxy-1-(3-pyridyl)-1-butanone-tetrafluorobenzoate. It was also used in the synthesis of N-[(4-carbamoylphenyl)carbamothioyl]-2,3,4,5-tetrafluorobenzamide.

InChI:InChI=1/C7HClF4O/c8-7(13)2-1-3(9)5(11)6(12)4(2)10/h1H

Upstream product

• 1201-31-6 2,3,4,5-tetrafluorobenzoic acid 
• 79-37-8 oxalyl dichloride 
• 75-09-2 dichloromethane 
• 68-12-2 N,N-dimethyl-formamide 
• 157766-28-4 2,3,4,5-tetraflurobenzotrichloride 
• 2414-98-4 magnesium ethylate 
• 105-53-3 diethyl malonate 

Downstream Products

• 887147-87-7 N,N'-diphenyl-N-(2,3,4,5-tetrafluorobenzoyl)guanidine 
• 887148-01-8 N-(5-phenyl-2H-pyrazol-3-yl)-2,3,4,5-tetrafluorobenzamide 
• 887148-07-4 N-(3-trifluoromethyl-1H-1,2,4-triazol-5-yl)-2,3,4,5-tetrafluorobenzamide 
• 912273-96-2 2,3,4,5-tetrafluoro(6-methoxybenzothiazol-2-yl)benzamide 
• 1006104-70-6 2-ethyl-1-(2,3,4,5-tetrafluorobenzoyl)isothiourea 
• 288157-63-1 4-[3-(2,3,4,5-tetrafluorobenzamidyl)benzoyl]-1-methylpiperidine 
• 94695-49-5 diethyl (2,3,4,5-tetrafluorobenzoyl)malonate 
• 94242-51-0 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester 
• 113865-66-0 tert-Butyl 2-cyano-3-oxo-3-(2,3,4,5-tetrafluorophenyl)-propionate 
• 158585-86-5 ethyl 6,8-difluoro-1,4-dihydro-1-(N-methylformamido)-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylate 
• 1109138-73-9 N-(2-chloroethyl)-2-(2,3,4,5-tetrafluorophenyl)acid amide 
• 1220124-37-7 2,3,4,5-tetrafluoro-N-methoxy-N-methylbenzamide 
• 1242560-02-6 ethyl 3-(1-adamantyl)-2-(2,3,4,5-tetrafluorobenzoyl)-3-oxopropanoate 
• 1542993-26-9 2-[5-(2,3,4,5-tetrafluorophenyl)-1,3,4-oxadiazol-2-yl]phenol 

Relevant articles and documents

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Preparation method of intermediate for synthesizing marbofloxacin

The invention discloses a preparation method of an intermediate for synthesizing marbofloxacin. The preparation method comprises the following steps: firstly, 2,3,4,5-tetrafluorobenzoic acid is subjected to a reaction with thionyl chloride, tetrafluorobenzoyl chloride is prepared and then subjected to a reaction with an ionic compound generated by the reaction of 3-(N-methyl-formylhydrazino)-ethylacrylate and magnesium ethoxide in an organic solvent, then the generated magnesium salt is washed by organic acid or inorganic acid, and the intermediate can be prepared. The method has high conversion rate and is suitable for industrial production.

General C-H Arylation Strategy for the Synthesis of Tunable Visible Light-Emitting Benzo[a]imidazo[2,1,5-c,d]indolizine Fluorophores

Herein we report the discovery of the benzo[a]imidazo[2,1,5-c,d]indolizine motif displaying tunable emission covering most of the visible spectrum. The polycyclic core is obtained from readily available amides via a chemoselective process involving Tf2O-mediated amide cyclodehydration, followed by intramolecular C-H arylation. Additionally, these fluorescent heterocycles are easily functionalized using electrophilic reagents, enabling divergent access to varied substitution. The effects of said substitution on the compounds' photophysical properties were rationalized by density functional theory calculations. For some compounds, emission wavelengths are directly correlated to the substituent's Hammett constants. Easily introduced nonconjugated reactive functional groups allow the labeling of biomolecules without modification of emissive properties. This work provides a straightforward platform for the synthesis of new moderately bright fluorescent dyes remarkable for their chemical stability, predictability, and unusually high excitation-emission differential.