947-84-2

Basic information

• Product Name: 2-Biphenylcarboxylic acid
• Synonyms: O-PHENYLBENZOIC ACID;TIMTEC-BB SBB007790;RARECHEM AL BE 0859;[1,1’-Biphenyl]-2-carboxylicacid;[1,1'-Biphenyl]-2-carboxylic acid;Biphenylcarboxylic acid-(2);DIPHENYL-2-CARBOXYLIC ACID;LABOTEST-BB LT00452563
• CAS NO: 947-84-2
• Molecular Formula: C₁₃H₁₀O₂
• Molecular Weight: 198.22
• EINECS: 213-432-1
• Product Categories: Benzene derivatives;Biphenyl derivatives;Organic acids;Biphenyl series
• Mol File: 947-84-2.mol
• Article Data: 107

Chemical Properties

• Melting Point: 111-113 °C(lit.)
• Boiling Point: 199 °C10 mm Hg(lit.)
• Flash Point: 343-344°C
• Appearance: White to beige/Crystalline Powder
• Density: 1.1184 (rough estimate)
• Vapor Pressure: 2.68E-05mmHg at 25°C
• Refractive Index: 1.5954 (estimate)
• Storage Temp.: Store below +30°C.
• PKA: 3.46(at 25℃)
• Water Solubility: insoluble
• BRN: 974075
• CAS DataBase Reference: 2-Biphenylcarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Biphenylcarboxylic acid(947-84-2)
• EPA Substance Registry System: 2-Biphenylcarboxylic acid(947-84-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39-37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 947-84-2(Hazardous Substances Data)

Usage

Chemical Properties

2-Biphenylcarboxylic acid is White powder

Uses

Different sources of media describe the Uses of 947-84-2 differently. You can refer to the following data:
1. 2-Biphenylcarboxylic acid is used in the preparation of neuropeptide FF receptor antagonists. In addition it is used in the synthesis of disubstituted piperidines as orexin receptor antagonists.
2. It is used as a pharmaceutical intermediate. he reaction of 2?-substituted biphenyl-2-carboxylic acids (where the 2?-substituent is H, CO2H, NO2, Cl, OMe, or CO2Me) with lead tetra-acetate in refluxing benzene solution, under a nitrogen atmosphere, affords 3,4-benzocoumarin as a major organic product.

Purification Methods

Crystallise the acid from *C6H6/pet ether or aqueous EtOH. [Beilstein 9 IV 2472.]

InChI:InChI=1/C13H10O2/c14-13(15)12-9-5-4-8-11(12)10-6-2-1-3-7-10/h1-9H,(H,14,15)/p-1

Upstream product

• 86-73-7 9H-fluorene 
• 115-86-6 phosphoric acid triphenyl ester 
• 54-21-7 sodium salicylate 
• 84-15-1 o-terphenyl 
• 1066-30-4 chromium(lll) acetate 
• 90128-01-1 2-chloro-7-phenyltropone 
• 91805-57-1 2-bromo-7-phenyl-cycloheptatrienone 
• 15719-64-9 methylammonium carbonate 
• 100-41-4 ethylbenzene 
• 94-36-0 dibenzoyl peroxide 
• 74-90-8 hydrogen cyanide 
• 84216-46-6 diphenic-mercuric acid anhydride 
• 643-58-3 2-methylbiphenyl 
• 19926-49-9 2-phenylbenzoic acid ethyl ester 

Downstream Products

• 16605-99-5 biphenyl-2-carboxylic acid methyl ester 
• 19926-49-9 2-phenylbenzoic acid ethyl ester 
• 2005-10-9 6H-benzo[c]chromen-6-one 
• 1015-89-0 phenanthridin-6-ol 
• 486-25-9 9-fluorenone 
• 18211-41-1 4'-nitro-[1,1'-biphenyl]-2-carboxylic acid 
• 13234-79-2 2-phenylbenzamide 
• 14002-52-9 o-phenylbenzoyl chloride 
• 97023-48-8 2-cyclohexylbenzoic acid 
• 114160-21-3 bicyclohexyl-2-carboxylic acid 
• 304-43-8 6β-(biphenyl-2-carbonylamino)-penicillanic acid 
• 17294-89-2 2'-nitro-biphenyl-2-carboxylic acid 
• 746-53-2 2,4,5,7-tetranitrofluoren-9-one 
• 1820-59-3 2,2',4,4'-tetranitro-1,1'-biphenyl 

Relevant articles and documents

Preparation method of acrylamido

The present invention relates to a method for preparing a pyrimidine, 9-fluorenone as raw material, by open loop, acid chloride, amidation, chlorination, Hofmann (Hofmann) rearrangement degradation to give 2-(4'-chlorophenyl) aniline, and then condensed with 2-chloronicotinamide to give the product acetoimide, the present invention also relates accordingly to the intermediates 4'-chloro-2-bibenzamide and 4'-chloro-2-aminobiphenyl preparation method. The method of the present invention can obtain the target product with high yield, high purity, and can reduce costs while reducing environmental harm.

Assemblies of 1,4-Bis(diarylamino)naphthalenes and Aromatic Amphiphiles: Highly Reducing Photoredox Catalysis in Water

Host-guest assemblies of a designed 1,4-bis(diarylamino)naphthalene and V-shaped aromatic amphiphiles consisting of two pentamethylbenzene moieties bridged by an m -phenylene unit bearing two hydrophilic side chains emerged as highly reducing photoredox catalysis systems in water. An efficient demethoxylative hydrogen transfer of Weinreb amides has been developed. The present supramolecular strategy permits facile tuning of visible-light photoredox catalysis in water.

Silica-coated magnetic nanoparticles functionalized cobalt complex: a recyclable and efficient catalyst for the C?C bond formation

In this study, the Co-based catalyst was prepared by cobalt immobilization on the surface of functionalized silica-coated magnetic NPs (Fe3O4@SiO2-CT-Co) as a magnetically core–shell nanocatalyst and characterized by FT-IR, TGA, XRD, VSM, SEM, TEM, EDX, EDX mapping, and ICP techniques and appraised in the Suzuki–Miyaura cross-coupling reaction under mild reaction conditions. The results displayed the superparamagnetic behavior of the Fe3O4 NPs core encapsulated by SiO2 shell, and the size of the particles was estimated about 30?nm. Compared with the previously reported catalysts, the engineered Fe3O4@SiO2-CT-Co catalyst provided perfect catalytic performance for the Suzuki–Miyaura cross-coupling reaction in water as a green solvent and it was much cheaper in the comparison with the traditional Pd-based catalysts. Importantly, the durability of magnetic nanocatalyst was studied and observed that it is stable under the reaction conditions and could be easily reused for at least six successive cycles without any significant decrease in its catalytic activity. Graphic abstract: [Figure not available: see fulltext.]