947012-80-8 Usage
Description
(6-Chloro-benzofuran-3-yl)-acetic acid is a chemical compound characterized by its molecular formula C10H7ClO3. It is a derivative of benzofuran, a heterocyclic compound, and features a chlorine atom and an acetic acid group within its structure. These elements confer both aromatic and acidic properties to the molecule, making it a versatile building block in the synthesis of pharmaceuticals and agrochemicals. Its structural features and biological activities also suggest potential applications in drug discovery and development, as well as in the fields of organic synthesis and medicinal chemistry.
Uses
Used in Pharmaceutical and Agrochemical Synthesis:
(6-Chloro-benzofuran-3-yl)-acetic acid is used as a key building block in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure and properties allow for the creation of a wide range of compounds with diverse applications, including therapeutic and pesticidal agents.
Used in Drug Discovery and Development:
Due to its structural features and biological activities, (6-Chloro-benzofuran-3-yl)-acetic acid is utilized in the field of drug discovery and development. Researchers can leverage its properties to design and develop new drugs with potential therapeutic benefits.
Used in Organic Synthesis and Medicinal Chemistry:
(6-Chloro-benzofuran-3-yl)-acetic acid also finds applications in the realms of organic synthesis and medicinal chemistry. Its chemical properties make it a valuable component in the creation of complex organic molecules and contribute to the advancement of chemical research and pharmaceutical innovation.
Check Digit Verification of cas no
The CAS Registry Mumber 947012-80-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,7,0,1 and 2 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 947012-80:
(8*9)+(7*4)+(6*7)+(5*0)+(4*1)+(3*2)+(2*8)+(1*0)=168
168 % 10 = 8
So 947012-80-8 is a valid CAS Registry Number.
947012-80-8Relevant articles and documents
Synthesis and preliminary evaluation of benzofuran-oxadiazole conjugates as potential antitubercular agents
Negalurmath, Veerabhadrayya S.,Kotresh, Obelannavar,Basanagouda, Mahantesha
, p. 965 - 970 (2019/03/07)
In the present study, a series of benzofuran-oxadiazole conjugates 7(a-o) was designed, synthesized and characterized through IR,1H NMR,13C NMR and mass spectral data. All the compounds were screened for preliminary antitubercular activity against Mycobacterium phlei and Mycobacterium tuberculosis H37RV. Among all the target compounds, the compound possessing chlorine (7k, MIC 1.56 μg/mL) and bromine (7m, MIC 1.56 μg/mL) on 6th position of benzofuran showed highest activity against Mycobacterium phlei. Whereas, bromine on either 5th position (7l, MIC 3.125 μg/mL) or 6th position (7m MIC 3.125 μg/mL) on benzofuran exhibited highest activity for Mycobacterium tuberculosis (H37 RV).
Efficient and Convenient Method for Synthesis of Benzofuran-3-acetic Acids and Naphthafuran-acetic Acids
Basanagouda, Mahantesha,Narayanachar,Majati, Iranna B.,Mulimani, Shiddappa S.,Sunnal, Satish B.,Nadiger, Rohit V.,Ghanti, Ashok S.,Gudageri, Siddeshwar F.,Naik, Ravi,Nayak, Akshata
supporting information, p. 2195 - 2202 (2015/09/22)
Herein, we report an efficient and convenient method for synthesis of benzofuran-3-acetic acids and naphthafuran-acetic acids 5a-p by the reaction of substituted-4-bromomethylcoumarins with aqueous sodium hydroxide at refluxing temperature. The obtained products are characterized by infrared, 1H NMR, 13C NMR, and mass spectral data. Structures 5a and 5e are confirmed by their single x-ray diffraction studies. The advantages of this method are good yields, easy workup, and no chromatographic purifications.
