947243-97-2

Basic information

• Product Name: 3-NITRO-4-[[(3,5,6-TRIMETHYL-2-PYRAZINYL)METHYL]AMINO]BENZOIC ACID ETHYL ESTER
• Synonyms: 3-NITRO-4-[[(3,5,6-TRIMETHYL-2-PYRAZINYL)METHYL]AMINO]BENZOIC ACID ETHYL ESTER
• CAS NO: 947243-97-2
• Molecular Formula: C₁₇H₂₀N₄O₄
• Molecular Weight: 0
• Mol File: 947243-97-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-NITRO-4-[[(3,5,6-TRIMETHYL-2-PYRAZINYL)METHYL]AMINO]BENZOIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-NITRO-4-[[(3,5,6-TRIMETHYL-2-PYRAZINYL)METHYL]AMINO]BENZOIC ACID ETHYL ESTER(947243-97-2)
• EPA Substance Registry System: 3-NITRO-4-[[(3,5,6-TRIMETHYL-2-PYRAZINYL)METHYL]AMINO]BENZOIC ACID ETHYL ESTER(947243-97-2)

Safety Data

• Hazardous Substances Data: 947243-97-2(Hazardous Substances Data)

Upstream product

• 76918-64-4 ethyl 4-amino-3-nitrobenzoate 
• 79074-45-6 2-(bromomethyl)-3,5,6-trimethylpyrazine 
• 1124-11-4 Tetramethylpyrazine 

Downstream Products

• 947243-77-8 N-(diaminomethylidene)-3-nitro-4-{[(3,5,6-trimethylpyrazin-2-yl)methyl]amino}benzamide hydrochloride 
• 947296-93-7 C₁₆H₁₉N₇O₃ 

Relevant articles and documents

Synthesis of novel ligustrazine derivatives as Na+/H+ exchange inhibitors

A novel series of 3,5,6-trimethylpyrazine-2-methoxy (or methylamino) substituted benzoyl-guanidine derivatives were designed and synthesized as Na+/H+ exchange (NHE) inhibitors. In this study, compounds with electron-withdrawing substituents on the benzene ring seemed to improve NHE-1 inhibitory activities. Compounds 6d, 6k, and 6l were found to be potent inhibitors of NHE-1 (IC50=3.0±1.6, 3.0±1.4, and 1.6±0.4nmol/l, resp.). Furthermore, they showed a remarkable reduction of infarct size in the rat myocardial infarction model in vivo.