949459-78-3

Basic information

• Product Name: Methoxy phenyl intemediate
• CAS NO: 949459-78-3
• Molecular Weight: 399.444
• Mol File: 949459-78-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Methoxy phenyl intemediate(CAS DataBase Reference)
• NIST Chemistry Reference: Methoxy phenyl intemediate(949459-78-3)
• EPA Substance Registry System: Methoxy phenyl intemediate(949459-78-3)

Safety Data

• Hazardous Substances Data: 949459-78-3(Hazardous Substances Data)

Upstream product

• 949459-79-4 methyl (4S,5S)-3-(tert-butoxycarbonyl)-2-(p-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-methanoate 

Downstream Products

• 859498-31-0 C₅₇H₆₁Cl₆NO₁₉ 

Relevant articles and documents

Dynamic kinetic resolution of α-chloro β-keto esters and phosphonates: Hemisynthesis of Taxotere through Ru-DIFLUORPHOS asymmetric hydrogenation

The dynamic kinetic resolution (DKR) of racemic α-chloro β-ketoesters and α-chloro β-ketophosphonates through ruthenium-mediated asymmetric hydrogenation is reported. The corresponding α-chloro β-hydroxyesters and α-chloro β- hydroxyphosphonates were obtained in good to high enantio- and diastereomeric excesses using, in particular, the atropisomeric ligand DIFLUORPHOS. This methodology allowed an efficient preparation of the anti phenylisoserine side chain of Taxotere which has been used for the hemisynthesis of the cancer therapeutic agent itself. In addition, 13C NMR in chiral oriented solvents was used to investigate the DKR effect.