949591-89-3

Basic information

• Product Name: N-{4-[(4-aminocyclohexyl)methyl]cyclohexyl}-N-(2-bromo-4,5-dimethoxybenzyl)-4-(1H-indol-3-yl)butanamide trifluoroacetic acid salt
• CAS NO: 949591-89-3
• Molecular Weight: 738.685
• Mol File: 949591-89-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-{4-[(4-aminocyclohexyl)methyl]cyclohexyl}-N-(2-bromo-4,5-dimethoxybenzyl)-4-(1H-indol-3-yl)butanamide trifluoroacetic acid salt(CAS DataBase Reference)
• NIST Chemistry Reference: N-{4-[(4-aminocyclohexyl)methyl]cyclohexyl}-N-(2-bromo-4,5-dimethoxybenzyl)-4-(1H-indol-3-yl)butanamide trifluoroacetic acid salt(949591-89-3)
• EPA Substance Registry System: N-{4-[(4-aminocyclohexyl)methyl]cyclohexyl}-N-(2-bromo-4,5-dimethoxybenzyl)-4-(1H-indol-3-yl)butanamide trifluoroacetic acid salt(949591-89-3)

Safety Data

• Hazardous Substances Data: 949591-89-3(Hazardous Substances Data)

Upstream product

• 133-32-4 4-indol-3-yl-butyric acid 
• 76-05-1 trifluoroacetic acid 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 

Relevant articles and documents

Design and synthesis of a library of tertiary amides: Evaluation as mimetics of the melanocortins' active core

Two hundred and ten tertiary amides were prepared on solid phase. Diamines were coupled to activated carboxylated Wang polymer, and the polymeric substituted benzyloxycarbonyl protected diamines obtained were reacted with aldehydes or ketones in trimethyl orthoformate giving resin attached Schiff bases. Coupled resins were then reduced to secondary amines by sodium cyanoborohydride in 4% acetic acid/trimethyl orthoformate, followed by acylation with the carboxylic acid in the presence of PyBroP and diisopropylethylamine. Cleavage of tertiary amides from the resin was made by trifluoroacetic acid in the presence of scavengers (mainly 1,2-ethanedithiol). When indole derivatives were prepared, parallel alkylation with the linker fragment occurred, giving derivatives of 2-(4-hydroxybenzyl)-indole as side products. Solution synthesis or mixed liquid/solid phase preparation of title substances proved to be advantageous in cases when the above method did not give acceptable results. According to this approach an efficient formation of Schiff bases was achieved in the presence of TiCl4. Substances were isolated by reversed phase chromatography; in some cases isomers were additionally separated by chiral chromatography on Chirobiotic T. When tested on human recombinant melanocortin receptors all the tertiary amides showed some binding affinities; for the highest affinity compounds the Kis reached 400 nM on MC1, 2 μM on MC3 and 1 μM on MC4 and MC5 receptors. cAMP assays of some of the title compounds showed that the tertiary amides are melanocortin receptor antagonists on the four MC receptor subtypes.