949922-62-7

Basic information

• Product Name: TERT-BUTYL 2-BROMO-6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-5(4H)CARBOXYLATE
• Synonyms: TERT-BUTYL 2-BROMO-6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-5(4H)CARBOXYLATE;2-Bromo-5-Boc-4,5,6,7-tetrahydrothieno[3,2-c]pyridine;2-c]pyridine-5(4H)-carboxylate;tert-butyl 2-broMo-4H,5H,6H,7H-thieno[3,2-c]pyridine-5-carboxylate;tert-Butyl 2-bromo-6,7-dihydrothieno[3,2-c]pyridine-5(4H);2-Bromo-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxylic acid tert-butyl ester;Thieno[3,2-c]pyridine-5(4H)-carboxylic acid, 2-bromo-6,7-dihydro-, 1,1-dimethylethyl ester
• CAS NO: 949922-62-7
• Molecular Formula: C₁₂H₁₆BrNO₂S
• Molecular Weight: 318.23
• Product Categories: CHIRAL CHEMICALS;Heterocycle-Pyridine series
• Mol File: 949922-62-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 382.8°Cat760mmHg
• Flash Point: 185.3°C
• Appearance: /
• Density: 1.445g/cm³
• Vapor Pressure: 4.59E-06mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -1.62±0.20(Predicted)
• CAS DataBase Reference: TERT-BUTYL 2-BROMO-6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-5(4H)CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 2-BROMO-6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-5(4H)CARBOXYLATE(949922-62-7)
• EPA Substance Registry System: TERT-BUTYL 2-BROMO-6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-5(4H)CARBOXYLATE(949922-62-7)

Safety Data

• Hazardous Substances Data: 949922-62-7(Hazardous Substances Data)

Usage

General Description

TERT-BUTYL 2-BROMO-6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-5(4H)CARBOXYLATE is a chemical compound that belongs to the class of organic compounds known as tetracyclic diterpenoids. It is a synthetic ester derivative of 4H-thieno[3,2-c]pyridine-5-carboxylic acid, which is commonly used as an intermediate in pharmaceutical and agrochemical synthesis. TERT-BUTYL 2-BROMO-6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-5(4H)CARBOXYLATE is primarily used in the development and production of various types of drugs, including antifungal and antiparasitic agents. It is also utilized in the manufacturing of crop protection products and insecticides. Additionally, TERT-BUTYL 2-BROMO-6,7-DIHYDROTHIENO[3,2-C]PYRIDINE-5(4H)CARBOXYLATE is considered a useful building block for the synthesis of diverse organic compounds, making it a valuable tool in chemical research and development.

InChI:InChI=1/C12H16BrNO2S/c1-12(2,3)16-11(15)14-5-4-9-8(7-14)6-10(13)17-9/h6H,4-5,7H2,1-3H3

Upstream product

• 230301-73-2 6,7-dihydro-4H-thieno[3,2-c]-pyridine-5-carboxylic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 28783-41-7 6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride 
• 226386-47-6 2-bromo-4,5,6,7-tetrahydrothieno[3,2-c]pyridine 

Downstream Products

• 150322-43-3 prasugel 
• 150322-38-6 5-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one 
• 1333429-06-3 2-(N-morpholinyl)-5-(alpha-cyclopropylcarbonyl-2-fluorobenzyl)-4.5.6.7-tetrahydro-thieno-[3,2-c]pyridine 
• 165947-48-8 5-tert-butoxycarbonyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid 
• 2246556-84-1 tert-butyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate 
• 165947-55-7 tert-butyl 2-(formyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate 
• 1613148-58-5 N,N-bis(tert-butoxycarbonyl)-5-(5-(tert-butoxycarbonyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)-3-(1-(2,5-difluorophenyl)ethoxy)pyridin-2-amine 
• 1613148-52-9 N,N-bis(tert-butoxycarbonyl)-5-(5-(tert-butoxycarbonyl)-4,5,6,7-tetrahydrothieno[3, 2-c]pyridin-2-yl)-3-(1-(5-chloro-2-(trifluoromethyl)phenyl)ethoxy)pyridin-2-amine 

Relevant articles and documents

Identification of 2-substituted pyrrolo[1,2-b]pyridazine derivatives as new PARP-1 inhibitors

A library of new 2-substituted pyrrolo[1,2-b]pyridazine derivatives were rapidly assembled and identified as PARP inhibitors. Structure-activity relationship for this class of inhibitor resulted in the discovery of most potent compounds 15a and 15b that e

Design and synthesis of 2-(4,5,6,7-tetrahydrothienopyridin-2-yl)-benzoimidazole carboxamides as novel orally efficacious Poly(ADP-ribose)polymerase (PARP) inhibitors

The nuclear protein poly(ADP-ribose) polymerases-1/2 (PARP-1/2) are involved in DNA repair damaged by endogenous or exogenous process. And PARP-1/2 inhibitors have been proved to be clinically efficacious for DNA repair deficient tumors in the past decade

A PROCESS FOR MAKING PRASUGREL

The present invention relates to A compound of general Formula (A), and/or acid addition salts thereof, wherein R is a hydrogen atom or a nitrogen-protecting group or an alpha- cyclopropylcarbonyl-2-fluorobenzyl group and R1,R2 is independently a C1-C10 alkyl group, optionally having one or more carbons substituted by a hydroxy group, or R1,R2 together with the bridging nitrogen may form a ring comprising from 3 to 10 carbon atoms, optionally also comprising another nitrogen, oxygen or sulfur atom in the ring and/or a nitrogen-, oxygen-, or sulfur-comprising substituent on the ring, to a process of making and use in making prasugrel.