95015-69-3

Basic information

• Product Name: L-Tyrosine, N-methyl-N-[(phenylmethoxy)carbonyl]-O-(phenylmethyl)-
• Synonyms: N-α-Carbobenzoxy-N-α-methyl-O-benzyl-L-tyrosine
• CAS NO: 95015-69-3
• Molecular Formula: C25H25NO5
• Molecular Weight: 419.477
• Mol File: 95015-69-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 601.9±55.0 °C (760 mmHg)
• Density: 1.235±0.06 g/cm3 (20 °C, 760 mmHg)
• CAS DataBase Reference: L-Tyrosine, N-methyl-N-[(phenylmethoxy)carbonyl]-O-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Tyrosine, N-methyl-N-[(phenylmethoxy)carbonyl]-O-(phenylmethyl)-(95015-69-3)
• EPA Substance Registry System: L-Tyrosine, N-methyl-N-[(phenylmethoxy)carbonyl]-O-(phenylmethyl)-(95015-69-3)

Safety Data

• Hazardous Substances Data: 95015-69-3(Hazardous Substances Data)

Upstream product

• 86827-18-1 N-benzyloxycarbonyl-O-benzyl-L-tyrosine 
• 7440-44-0 pyrographite 
• 74-88-4 methyl iodide 
• 225386-51-6 phenylmethyl (4S)-5-oxo-4-({4-[(phenylmethyl)oxy]phenyl}methyl)-1,3-oxazolidine-3-carboxylate 

Downstream Products

• 95015-70-6 Z-(Me)Tyr(Bzl)-(Me)Ava-(Me)PHA 
• 205874-99-3 N-(N^α-benzyloxycarbonyl-N^α-methyl-O-benzyltyrosyl-N^g-tosylarginyl)ethanamine 
• 205874-98-2 N¹-benzyloxycarbonyl-N²-(N^α-benzyloxycarbonyl-N^α-methyl-O-benzyltyrosyl-N^g-tosylarginyl)-1,2-ethanediamine 
• 205875-00-9 N-(N^α-benzyloxycarbonyl-N^α-methyl-O-benzyltyrosyl-N^g-tosylarginyl)bis(4-methylphenyl)methanamine 
• 205874-97-1 N¹-benzyloxycarbonyl-N⁵-(N^α-benzyloxycarbonyl-N^α-methyl-O-benzyltyrosyl-N^g-tosylarginyl)-1,5-pentanediamine 
• 175216-34-9 N¹-benzyloxycarbonyl-N⁸-(N^α-benzyloxycarbonyl-N^α-methyl-O-benzyltyrosyl-N^g-tosylarginyl)-1,8-octanediamine 
• 205874-96-0 N¹-benzyloxycarbonyl-N⁸-(N^α-benzyloxycarbonyl-N^α-methyl-O-benzyltyrosylleucyl-D-leucyl-D-leucyl)-1,8-octanediamine 
• 205874-83-5 N¹-benzyloxycarbonyl-N⁸-(N^α-benzyloxycarbonyl-N^α-methyl-O-benzyltyrosylleucyl-N^α-methyl-N^g-nitroarginyl-D-leucyl)-1,8-octanediamine 
• 205874-81-3 N-(N^α-benzyloxycarbonyl-N^α-methyl-O-benzyltyrosyl-N^g-tosylarginyl-N^α-methyl-N^g-tosylarginyl-D-leucyl)ethanamine 
• 205874-82-4 N^α-benzyloxycarbonyl-N^α-methyl-O-benzyltyrosyl-N^g-tosylarginyl-N^α-methyl-N^g-tosylarginyl-D-leucine benzyl ester 
• 95015-80-8 5-{[(S)-3-(4-Hydroxy-phenyl)-2-methylamino-propionyl]-methyl-amino}-pentanoic acid methyl-phenethyl-amide; hydrochloride 

Relevant articles and documents

A simple and rapid protocol for N-methyl-α-amino acids

A two step strategy for optically pure N-Protected-N-methyl-α-amino acids starting from N-protected-α-amino acids via reductive cleavage of oxazolidinones using NaCNBH3/TMSCl is described.

Intestinal absorption of fluorescence-derivatized cationic peptide 001-C8-NBD via adsorptive-mediated transcytosis

The intestinal absorption of an intact oligopeptide was investigated in rats using a synthetic cationic peptide, 001-C8 (H-MeTyr-Arg-MeArg-d-Leu-NH(CH2)8NH2). The peptide was coupled with 4-nitrobenzo-2-oxa-1,3-diazole (NBD) to prepare a fluorescence-labeled derivative 001-C8-NBD (H-MeTyr-Arg-MeArg-d-Leu-NH(CH2)8NH-NBD) for the purpose of quantification. The degradation half-life of 001-C8-NBD in jejunal homogenate (1mg/mL) was 99.5min, which was significantly longer than that of natural leucine enkephalin (1.14min). The absorption of 001-C8-NBD was evaluated by the vascular-perfusion method. Intact 001-C8-NBD appeared in the blood time-dependently and the absorption volume at 30min (2.75 ± 0.14μL/cm intestine) was significantly larger than that of [3H]PEG 900 (0.88 ± 0.13μL/cm intestine), of which membrane permeability is very low. The absorption of 001-C8-NBD was greatly reduced by an adsorptive-mediated endocytosis inhibitor, protamine (10mM). No inhibition of the absorption of [3H]PEG 900 by protamine was observed. The intestinal absorption was also measured by an in vivo loop method. The absorption clearance of 001-C8-NBD measured by this method (0.083 ± 0.008μL/min/cm intestine) was comparable to that obtained by the vascular perfusion method (0.092 ± 0.005μL/min/cm intestine). All of these data suggested that 001-C8-NBD was absorbed as the intact oligopeptide in the intestine in vivo. Adsorptive-mediated transcytosis is suggested to have enormous potential as an oral delivery system for peptide and/or protein drugs. Copyright (C) 1998 Elsevier Science Ltd.

Analgesic dipeptide amides and method of use and compositions thereof

A genus of dipeptide amides including as the preferred subgenus the dipeptide amides having the structural formula R1 TyrR2 D-AlaNHR4 wherein R1 and R2 are each hydrogen or alkyl provided that at least one of them is other than hydrogen and R4 is phenylalkyl or substituted-phenylalkyl are prepared by condensing the dipeptide with the amine or the amino acid with the amino acid amide and are useful as analgesics.