950455-15-9 Usage
Description
Liproxstatin-1 is a ferroptosis inhibitor that effectively inhibits ferroptotic cell death and lipid peroxidation in various cell types. It is a potent antioxidant that traps peroxyl radicals and prevents autooxidation of lipids.
Used in Pharmaceutical Industry:
Liproxstatin-1 is used as a cell death inhibitor for the treatment of diseases associated with ferroptosis, such as neurodegenerative disorders, ischemic injuries, and certain types of cancer. Its ability to inhibit ferroptosis and lipid peroxidation makes it a promising therapeutic agent for improving cell survival and reducing tissue injury in various conditions.
Used in Research Applications:
Liproxstatin-1 is used as a cell viability assay tool for studying the mechanisms of ferroptosis and identifying potential therapeutic targets. It is also used for the determination of lipid peroxidation, providing valuable insights into the role of oxidative stress in various diseases and conditions.
Biochem/physiol Actions
Liproxstatin-1 is a potent inhibitor of ferroptosis, a non-apoptotic form of cell death characterized by iron-dependent accumulation of lethal lipid reactive oxygen species (ROS). Liproxstatin-1 suppressed ferroptosis in human cells and in an ischaemia/reperfusion-induced tissue injury model in mice. Knockout of glutathione peroxidase 4 (Gpx4) Has been shown to cause cell death by ferroptosis. Liproxstatin-1 was able to suppress ferroptosis in Gpx4 knock-out mice.
References
Angeli et al. (2014), Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice; Nat. Chem. Biol. 16 1180
Feng et al. (2019), Liproxstatin-1 protects the mouse myocardium against ischemia/reperfusion injury by decreasing VDAC1 levels and restoring GPX4 levels; Biochem. Biophys. Res. Commun. 520 606
Zilka et al. (2017), On the mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death; ACS Cent. Sci. 3 232
Check Digit Verification of cas no
The CAS Registry Mumber 950455-15-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,0,4,5 and 5 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 950455-15:
(8*9)+(7*5)+(6*0)+(5*4)+(4*5)+(3*5)+(2*1)+(1*5)=169
169 % 10 = 9
So 950455-15-9 is a valid CAS Registry Number.
950455-15-9Relevant articles and documents
SPIROQUINOXALINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH
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Page/Page column 186; 187; 189; 190, (2015/02/02)
The present invention relates to compounds which are inhibitors of non-apoptotic regulated cell death, and to pharmaceutical compositions containing such compounds. Furthermore, the present invention relates to the use of such compounds and pharmaceutical compositions in therapy, in particular in the treatment of a condition, disorder or disease that is characterised by non-apoptotic regulated cell-death or where non-apoptotic regulated cell-death is likely to play or plays a substantial role. The compounds and pharmaceutical compositions described herein are also useful in the treatment of a condition, disorder or disease that is characterised by oxidative stress or where oxidative stress is likely to play or plays a substantial role; and/or a condition, disorder or disease that is characterised by activation of (1) one or more components of the necrosome; (2) death domain receptors; and/or (3) Toll-like receptors; and/or (4) players in ferroptotic/ferroptosis signalling, or where activation of any one of (1) to (3) and/or (4) is likely to play or plays a substantial role.
