95091-21-7Relevant articles and documents
Conformational Analysis of Acyclic α-Fluoro Sulfur Motifs
Erdeljac, Nathalie,Mück-Lichtenfeld, Christian,Daniliuc, Constantin G.,Gilmour, Ryan
, p. 13704 - 13715 (2020/10/02)
Bioactive small molecules containing α-fluoro sulfur motifs [RS(O)nCH2F] are appearing with increasing frequency in the pharmaceutical and agrochemical sectors. Prominent examples include the anti-asthma drug Flovent and t
THIOREDOXIN AND THIOREDOXIN REDUCTASE INHIBITORS
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Page/Page column 58; 13/22; 14/22, (2008/06/13)
The present invention relates to sulfone derivatives and to their use as modulators of the thioredoxin/thioredoxin reductase redox system, including for the treatment and/or prevention of pathophysiological conditions mediated by thioredoxin/thioredoxin reductase, such as cancer, HIV/ AIDS, Alzheimer's disease, rheumatoid arthritis, and skin disorders. Also provided are pharmaceutical compositions comprising the inventive sulfones.