951207-70-8

Basic information

• Product Name: UIC 98,056
• Synonyms: UIC 98,056
• CAS NO: 951207-70-8
• Molecular Weight: 802.001
• Mol File: 951207-70-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: UIC 98,056(CAS DataBase Reference)
• NIST Chemistry Reference: UIC 98,056(951207-70-8)
• EPA Substance Registry System: UIC 98,056(951207-70-8)

Safety Data

• Hazardous Substances Data: 951207-70-8(Hazardous Substances Data)

Upstream product

• 138499-08-8 1-({[(3S)-tetrahydro-3-furanyloxy]carbonyl}oxy)-2,5-pyrrolidinedione 

Relevant articles and documents

Protease inhibitors that overcome drug resistance

HIV protease inhibitors are among the most powerful drugs in suppressing HIV in human patients. However, HIV developed resistance to all protease inhibitor drugs so far marketed or used in clinical trials. HIV generates resistance by mutating its protease. The strains of HIV containing mutant proteases less vulnerable to inhibitor drug are able to replicate better and maintain the infection. No effective principle exists for the design of resistance-proof HIV protease inhibitors (HIVPr). A new inhibitor has been developed based on a new concept for designing resistance invulnerable HIVPr inhibitors. In vitro data have shown that this inhibitor is effective against many known HIVPr mutants resistant to other HIVPr inhibitor drugs. The new concept is, therefore, generally applicable for the design of other resistance invulnerable HIVPr inhibitor drugs.