951887-33-5

Basic information

• Product Name: 2-IODO-3'-METHYLBENZOPHENONE
• Synonyms: 2-IODO-3'-METHYLBENZOPHENONE
• CAS NO: 951887-33-5
• Molecular Formula: C₁₄H₁₁IO
• Molecular Weight: 322.14
• Mol File: 951887-33-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-IODO-3'-METHYLBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-IODO-3'-METHYLBENZOPHENONE(951887-33-5)
• EPA Substance Registry System: 2-IODO-3'-METHYLBENZOPHENONE(951887-33-5)

Safety Data

• Hazardous Substances Data: 951887-33-5(Hazardous Substances Data)

Upstream product

• 133776-41-7 anthranilic acid N-methoxy-N-methylamide 
• 118-92-3 anthranilic acid 
• 591-17-3 meta-bromotoluene 
• 62261-47-6 (2-aminophenyl)(3-methylphenyl)methanone 

Downstream Products

• 1370697-69-0 C₂₃H₁₈O₂ 
• 1370697-62-3 1,3-diiodo-2-phenyl-4-(m-tolyl)naphthalene 
• 1370697-39-4 1-(2-((4-methoxyphenyl)ethynyl)phenyl)-3-phenyl-1-(m-tolyl)prop-2-yn-1-ol 

Relevant articles and documents

Novel transformation of aryl 2-iodophenyl ketones into 1,3-diarylisoquinolines with (TMS)2NH, styrenes, NIS, and tBuOK

Treatment of aryl 2-iodophenyl ketones with TMS2NH in the presence of Sc(OTf)3 at warming conditions, followed by the reaction with styrenes and NIS gave N-(1-aryl-2-iodoethyl) aryl 2-iodophenyl ketimines. Further treatment of N-(1-aryl-2-iodoethyl) aryl 2-iodophenyl ketimines with tBuOK in the presence of 1,10-phenanthroline at 120 °C generated 1,3-diarylisoquinolines in moderate yields through SET from tBuOK onto the iodophenyl group to form aryl radicals, their 6-endo-trig cyclization onto the vinyl groups, and aromatization of the cyclized intermediates. The present method is a novel approach for the preparation of the isoquinoline core via two steps from aryl 2-iodophenyl ketones.

Palladium-Catalyzed Cascade Reductive and Carbonylative Cyclization of Ortho-Iodo-Tethered Methylenecyclopropanes (MCPs) Using N-Formylsaccharin as CO Source

A palladium-catalyzed reductive and carbonylative cyclization of ortho-iodo-tethered methylenecyclopropanes (MCPs) using N-formylsaccharin as CO source has been developed, affording the desired indanone derivatives in moderate to good yields with high regio- and stereoselectivity and good functional group compatibility.