951889-75-1

Basic information

• Product Name: 4-TERT-BUTYL-2'-IODOBENZOPHENONE
• Synonyms: 4-TERT-BUTYL-2'-IODOBENZOPHENONE;(4-tert-butylphenyl)-(2-iodophenyl)methanone;Methanone, [4-(1,1-dimethylethyl)phenyl](2-iodophenyl)-
• CAS NO: 951889-75-1
• Molecular Formula: C17H17IO
• Molecular Weight: 364.22
• Mol File: 951889-75-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-TERT-BUTYL-2'-IODOBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-TERT-BUTYL-2'-IODOBENZOPHENONE(951889-75-1)
• EPA Substance Registry System: 4-TERT-BUTYL-2'-IODOBENZOPHENONE(951889-75-1)

Safety Data

• Hazardous Substances Data: 951889-75-1(Hazardous Substances Data)

Upstream product

• 88-67-5 2-Iodobenzoic acid 
• 253185-03-4 tert-butylbenzene 
• 609-67-6 2-Iodobenzoyl chloride 
• 133776-41-7 anthranilic acid N-methoxy-N-methylamide 
• 461694-82-6 (2-aminophenyl)[4-(tert-butyl)phenyl]methanone 
• 118-48-9 isatoic anhydride 
• 3972-65-4 1-bromo-4-tert-butylbenzene 

Relevant articles and documents

Novel transformation of aryl 2-iodophenyl ketones into 1,3-diarylisoquinolines with (TMS)2NH, styrenes, NIS, and tBuOK

Treatment of aryl 2-iodophenyl ketones with TMS2NH in the presence of Sc(OTf)3 at warming conditions, followed by the reaction with styrenes and NIS gave N-(1-aryl-2-iodoethyl) aryl 2-iodophenyl ketimines. Further treatment of N-(1-aryl-2-iodoethyl) aryl 2-iodophenyl ketimines with tBuOK in the presence of 1,10-phenanthroline at 120 °C generated 1,3-diarylisoquinolines in moderate yields through SET from tBuOK onto the iodophenyl group to form aryl radicals, their 6-endo-trig cyclization onto the vinyl groups, and aromatization of the cyclized intermediates. The present method is a novel approach for the preparation of the isoquinoline core via two steps from aryl 2-iodophenyl ketones.

Cu(I)-Catalyzed Coupling and Cycloisomerization of Diazo Compounds with Terminal Yne-Alkylidenecyclopropanes: Synthesis of Functionalized Cyclopenta[ b]naphthalene Derivatives

A Cu(I)-catalyzed coupling and cycloisomerization of diazo compounds with terminal yne-alkylidenecyclopropanes (ACPs) has been presented. This reaction starts from the formation of an allenic intermediate in the Cu(I)-catalyzed cross-coupling reaction of a diazo compound with terminal alkyne in yne-tethered ACP and then undergoes a domino cycloisomerization of a 6π-electrocyclization and cyclopropane ring-opening rearrangement to give functionalized cyclopenta[b]naphthalene derivatives in moderate to excellent yields under mild conditions.