95233-37-7

Basic information

• Product Name: 4-(4-Chlorophenyl)cyclohexanecarboxylic acid
• Synonyms: CPCCA;(E)-4-(4-Chlorophenyl)cyclohexanecarboxylic acid;4-(4-Chlorophenyl)cyclohexylcarboxylic acid;4-(4'-Chlorophenyl)cyclohexancarboxylicacid;4,4-DIMETHYL-6-ETHYNYLTHIOCHROMAN[FOR TAZAROTENE];4-(4-Chlorophenyl)cyclohexanecarboxylic acid;4-(P-CHLOROPHENYL)CYCLOHEXANECARBOXYLICACID;4-(trans-4-Carboxycyclohexyl)chlorobenzene
• CAS NO: 95233-37-7
• Molecular Formula: C₁₃H₁₅ClO₂
• Molecular Weight: 238.71
• Mol File: 95233-37-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 250 °C
• Boiling Point: 387.1 °C at 760 mmHg
• Flash Point: 187.9 °C
• Appearance: /
• Density: 1.225 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.80±0.10(Predicted)
• CAS DataBase Reference: 4-(4-Chlorophenyl)cyclohexanecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Chlorophenyl)cyclohexanecarboxylic acid(95233-37-7)
• EPA Substance Registry System: 4-(4-Chlorophenyl)cyclohexanecarboxylic acid(95233-37-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 26-36/37/39-22
• Hazardous Substances Data: 95233-37-7(Hazardous Substances Data)

Usage

Uses

4-(4-Chlorophenyl)cyclohexanecarboxylic Acid is a reactant used in the synthesis of novel hydrazone derivatives as antimicrobial agents.

Upstream product

• 49708-48-7 4-(4-Chloro-phenyl)-cyclohex-3-enecarboxylic acid 
• 106-39-8 bromochlorobenzene 
• 874-61-3 4-oxocyclohexanecarboxylic acid 
• 91161-85-2 trans-4-(p-chlorophenyl)-1-acetyl-cyclohexane 
• 3618-03-9 methyl 4-hydroxycyclohexanecarboxylate 
• 128208-09-3 methyl trans-4-(4-chlorophenyl)cyclohexane-1-carboxylate 

Downstream Products

• 129719-64-8 2-[4-(4-chlorophenyl)-cyclohexyl]-3-chloro-1,4-naphthoquinone 
• 137736-28-8 [trans-4-(4-chlorophenyl)cyclohexyl]methanol 
• 930766-09-9 4-(4-chlorophenyl)cyclohexan-1-ol 
• 94015-53-9 atovaquone 

Relevant articles and documents

A pharmaceutical intermediate 4 - (4 - chlorophenyl) cyclohexyl -1 - formic acid

The invention belongs to the field of preparation of drug intermediates and particularly relates to a synthesis method of a drug intermediate 4-(4-chlorphenyl) cyclohexyl-1-formic acid. The method comprises the following steps: firstly reacting a compound I with R2SO2Cl in the presence of an acid-binding agent to obtain a compound II; carrying out catalytic coupling reaction on the compound II and a Grignard reagent 4-chlorphenyl magnesium halide under the action of a catalyst to obtain a compound III; and finally hydrolyzing the compound III in alkali liquor to obtain a target product 4-(4-chlorphenyl) cyclohexyl-1-formic acid. According to the synthesis method, all steps in a reaction route are exclusive reactions; and ortho-position and meta-position problems in friedel-crafts reaction are overcome, so that the utilization rate of raw materials is high; the total yield is high; and the cost is low. A main body structure is constructed by a coupling technique, so that the problem that hydrolysate which is formed after a lot of lewis acid used in the friedel-crafts reaction is hydrolyzed needs to be subjected to special treatment is overcome; the method is environment-friendly; and industrialized production is facilitated.

Method for treating animals infected with Babesia spp.

The present invention relates to pharmaceutical compositions for the treatment and/or prophylaxis of protozoal infections caused by Kinetoplastida, Apicomplexa, Anaerobic protozoa and Mircosporidia comprising 2-[4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone or a physiologically acceptable salt or other functional derivative thereof as active ingredient and to a method of treating or preventing siad protozoal infections in an animal which comprises administering to said animal an effective amount of siad compound.

Medicaments

A method and certain compositions for treating Pneumocystis carinii infections in a mammal by administering a certain naphthoquinone compound or physiologically acceptable salts thereof.