95264-40-7

Basic information

• Product Name: 4,6-DIMETHYL-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 4,6-DIMETHYL-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER;ETHYL 4,6-DIMETHYL-1H-INDOLE-2-CARBOXYLATE
• CAS NO: 95264-40-7
• Molecular Formula: C13H15NO2
• Molecular Weight: 217.26
• Mol File: 95264-40-7.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4,6-DIMETHYL-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-DIMETHYL-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER(95264-40-7)
• EPA Substance Registry System: 4,6-DIMETHYL-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER(95264-40-7)

Safety Data

• Hazardous Substances Data: 95264-40-7(Hazardous Substances Data)

Usage

General Description

4,6-DIMETHYL-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER is a chemical compound that belongs to the class of esters. It is derived from the carboxylic acid 4,6-dimethyl-1H-indole-2-carboxylic acid and ethyl alcohol. 4,6-DIMETHYL-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs, including anti-inflammatory and antiviral agents. It has also been studied for its potential biological and pharmacological activities, such as its ability to inhibit certain enzymes and receptors in the body. However, its exact mechanisms of action and potential therapeutic applications are still being researched.

Upstream product

• 617-35-6 2-oxo-propionic acid ethyl ester 
• 210536-89-3 N-(3,5-dimethylphenyl) benzophenone hydrazone 
• 15764-16-6 2,4-dimethylbenzaldehyde 
• 60481-36-9 (3,5-dimethylphenyl)hydrazine hydrochloride 
• 108-69-0 3,5-dimethylaminoaniline 

Downstream Products

• 383132-27-2 4,6-dimethyl-1H-indole-2-carboxylic acid 
• 1432642-16-4 N-cyclohexyl-1,4,6-trimethyl-1H-indole-2-carboxamide 
• 1432642-01-7 N-cyclohexyl-N,4,6-trimethyl-1H-indole-2-carboxamide 
• 1432641-94-5 N-(cyclohexylmethyl)-4,6-dimethyl-1H-indole-2-carboxamide 
• 883014-15-1 N-(3-fluoro-4-methylphenyl)-4,6-dimethyl-1H-indole-2-carboxamide 
• 701202-07-5 4,6-dimethyl-N-phenyl-1H-indole-2-carboxamide 
• 883016-34-0 N-cyclohexyl-4,6-dimethyl-1H-indole-2-carboxamide 
• 647009-88-9 2-hydroxymethyl-4,6-dimethylindole 

Relevant articles and documents

INDOLE CARBOXAMIDE COMPOUNDS AND USE THEREOF FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS

Provided herein are compounds of Formula (I) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of tuberculosis.

Carboxylic Acid-Promoted Single-Step Indole Construction from Simple Anilines and Ketones via Aerobic Cross-Dehydrogenative Coupling

The cross-dehydrogenative coupling (CDC) reaction is an efficient strategy for indole synthesis. However, most CDC methods require special substrates, and the presence of inherent groups limits the versatility for further transformation. A carboxylic acid-promoted aerobic catalytic system is developed herein for a single-step synthesis of indoles from simple anilines and ketones. This versatile system is featured by the broad substrate scope and the use of ambient oxygen as an oxidant and is convenient and economical for both laboratory and industry applications. The existence of the labile hydrogen at C-3 and the highly transformable carbonyl at C-2 makes the indoles versatile building blocks for organic synthesis in different contexts. Computational studies based on the density functional theory (DFT) suggest that the rate-determining step is carboxylic acid-assisted condensation of the substrates, rather than the functionalization of aryl C-H. Accordingly, a pathway via imine intermediates is deemed to be the preferred mechanism. In contrast to the general deduction, the in situ formed imine, instead of its enamine isomer, is believed to be involved in the first ligand exchange and later carbopalladation of the α-Me, which shed new light on this indolization mechanism.

INHIBITORS OF DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS

The present invention provides novel indoleamide compounds for treating tuberculosis, including drug-resistant M-tuberculosis, compositions comprising the indoleamides and methods of using the indoleamides in conjunction with other biologically active agents for the treatment of tuberculosis in a subject in need thereof.