953053-80-0

Basic information

• Product Name: (2E)-4-[[(4-methylphenyl)sulfonyl][2-[(1E)-[(phenylmethoxy)imino]methyl]phenyl]amino]-2-butenenitrile
• CAS NO: 953053-80-0
• Molecular Weight: 445.542
• Mol File: 953053-80-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2E)-4-[[(4-methylphenyl)sulfonyl][2-[(1E)-[(phenylmethoxy)imino]methyl]phenyl]amino]-2-butenenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-4-[[(4-methylphenyl)sulfonyl][2-[(1E)-[(phenylmethoxy)imino]methyl]phenyl]amino]-2-butenenitrile(953053-80-0)
• EPA Substance Registry System: (2E)-4-[[(4-methylphenyl)sulfonyl][2-[(1E)-[(phenylmethoxy)imino]methyl]phenyl]amino]-2-butenenitrile(953053-80-0)

Safety Data

• Hazardous Substances Data: 953053-80-0(Hazardous Substances Data)

Upstream product

• 90312-02-0 N-(2-hydroxymethylphenyl)-4-methylbenzenesulfonamide 
• 6590-65-4 N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide 
• 953053-76-4 4-methyl-N-[[2-[(1E)-(phenylmethoxy)imino]methyl]phenyl]benzenesulfonamide 
• 42879-03-8 4-bromobut-2-enenitrile 

Relevant articles and documents

Development of radical addition-cyclization-elimination reaction of oxime ether and its application to formal synthesis of (±)-martinelline

Radical addition-cyclization-elimination (RACE) reaction of oxime ether carrying unsaturated ester provides a novel method for the construction of pyrroloquinoline. Treatment of oxime ethers with Bu3SnH and AIBN gave N-norpyrroloquinoline as a major product, which was also obtained by the radical reaction of the corresponding hydrazone and imine. The radical reaction of aldehyde and ketone carrying unsaturated ester proceeded stereoselectively to give cis-furoquinolines and cis-hydroxyesters. The RACE reactions by using each of Bu3SnNMe2, Bu3SnD, and/or D2O were also examined in order to propose a reaction pathway to N-norpyrroloquinoline. Furthermore, the synthetic utility of RACE reaction is demonstrated by preparation of a key intermediate for the synthesis of (±)-martinelline.