95341-80-3Relevant articles and documents
Enantioselective Cyclopropanation of 1,1-Diphenylethylene and Diazoacetic Acid Ester with Copper Catalysts
Brunner, Henri,Miehling, Wolfgang
, p. 1237 - 1254 (1984)
Copper(II) compounds catalyze the reaction of 1,1-diphenylethylene with diazoacetic acid ethylester.The main product is 2,2-diphenylcyclopropane carboxylic acid ethylester.The formation of the carbene dimerization products fumaric and maleic acid diethylester can be suppressed by the continuous addition of diazoacetic ester to 1,1-diphenylethylene. 37 optically active ligands, partly new, were combined with copper(II)-acetate to give in-situ-catalysts.In five cases isolated copper complexes were used as catalysts.The best optical inductions in the formation of 2,2-diphenylcyclopropane carboxylic acid ethylester with up to 65.6percent ee were achived with Schiffbase ligands, which derive from salicylaldehyde and amino alcohols, obtained from amino acid esters and phenyl Grignard. - Keywords: Catalytic enantioselective cyclopropanation; Copper(II) catalysts; Optical induction.
Derivatives of (R) and (S)-2-amino-1-butanol as possible anti-arrhythmics
Kumar, G. Biju,Shah, A. C.
, p. 79 - 82 (2007/10/03)
The chiral imines derived from (R) and (S)-2-amino-1-butanol have been reported.Some of the chiral imines have been found to be in equilibrium with the corresponding 1,3-oxazolidines, which on treatment with sodium borohydride in methanol are reduced to the corresponding N-benzyl derivatives.
