95351-73-8Relevant articles and documents
Direct synthesis of thiols from halides and epoxides using hydrosulfide exchange resin in methanol
Choi,Yoon
, p. 373 - 375 (1995)
Various thiols are prepared directly from the corresponding alkyl halides and epoxides using hydrosulfide exchange resin in methanol in the presence of equimolar amounts of triethylammonium chloride at room temperature. The reaction not only proceeds with unique chemoselectivity, but also gives better yields of thiols than most commonly used indirect methods and has an additional advantage of a simple workup.
Highly enantioselective reactions of a lithiated α-thioallyl carbanion via thermodynamic resolution pathway
Sonawane, Ravindra P.,Froehlich, Roland,Hoppe, Dieter
, p. 1847 - 1854 (2007/10/03)
S-Cinnamyl thiocarbamate 9, easily accessible from cinnamyl alcohol, undergoes smooth deprotonation with n-BuLi in the presence of various chiral ligands to form configurationally unstable organolithium intemediates. With the proper choice of chiral ligand, the diastereomeric equilibrium is almost fully shifted to one side, furnishing highly enantioenriched products after reaction with various electrophiles.
6-O-acyl ketolide antibacterials
-
, (2008/06/13)
6-O-Acyl ketolide antibacterials of the formula: wherein R1, R2, R3, R4, W, X, X′, Y, and Y′ are as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.