954230-26-3 Usage
Description
4-Isoxazolecarboxylic acid, 3-(4-bromophenyl)-5-methyl-, ethyl ester is a chemical compound with the molecular formula C13H12BrNO3. It is a derivative of isoxazolecarboxylic acid, which has potential biological and pharmacological applications. As an ethyl ester derivative, it is commonly used as a reagent in organic synthesis. The presence of the bromophenyl and methyl groups in its structure suggests that it may have specific applications in medicinal and pharmaceutical research, potentially serving as a building block for the development of new drugs or therapeutic compounds.
Uses
Used in Pharmaceutical Research:
4-Isoxazolecarboxylic acid, 3-(4-bromophenyl)-5-methyl-, ethyl ester is used as a building block for the development of new drugs or therapeutic compounds due to its unique structure and potential biological activity.
Used in Organic Synthesis:
4-Isoxazolecarboxylic acid, 3-(4-bromophenyl)-5-methyl-, ethyl ester is used as a reagent in organic synthesis, allowing for the creation of various chemical compounds and materials.
Used in Medicinal Chemistry:
4-Isoxazolecarboxylic acid, 3-(4-bromophenyl)-5-methyl-, ethyl ester is used in medicinal chemistry for the design and synthesis of novel compounds with potential therapeutic applications.
Used in Chemical Research:
4-Isoxazolecarboxylic acid, 3-(4-bromophenyl)-5-methyl-, ethyl ester is used in chemical research to study its properties, reactivity, and potential applications in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 954230-26-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,4,2,3 and 0 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 954230-26:
(8*9)+(7*5)+(6*4)+(5*2)+(4*3)+(3*0)+(2*2)+(1*6)=163
163 % 10 = 3
So 954230-26-3 is a valid CAS Registry Number.
954230-26-3Relevant articles and documents
Lysophosphatidic acid receptor antagonists and preparation method thereof
-
, (2020/07/29)
The invention belongs to the technical field of medicinal chemistry, and particularly relates to lysophosphatidic acid receptor antagonists and a preparation method thereof. The applicant surprisinglyfinds that compounds provided by the invention have high LPAR1 antagonistic activity and selectivity, low toxicity, good metabolic stability and good drug development prospect, and can be used for preventing or treating diseases or symptoms related to LPAR1. The applicant also accidentally finds that the IC50 value of part of the compounds can be as low as 300 nM or below and even 50 nM or below.Moreover, the compounds disclosed by the invention have better safety, and the CC50 range of the compounds can reach 200 [mu]M or above. In addition, the compounds of the present invention have goodmetabolic stability in humans, rats, and mice, such excellent inhibitory activity being very desirable for their use as LPAR1 inhibitors in the above diseases or disorders. In addition, the preparation method of the compounds is simple, mild in reaction condition, high in product yield and suitable for industrial production.
Dimeric isoxazolyl-1,4-dihydropyridines have enhanced binding at the multi-drug resistance transporter
Steiger, Scott A.,Li, Chun,Backos, Donald S.,Reigan, Philip,Natale
, p. 3223 - 3234 (2017/05/29)
A series of dimeric isoxazolyl-1,4-dihydropyridines (IDHPs) were prepared by click chemistry and examined for their ability to bind the multi-drug resistance transporter (MDR-1), a member of the ATP-binding cassette superfamily (ABC). Eight compounds in t
