954240-02-9

Basic information

• Product Name: [3-(3-FLUORO-PHENYL)-ISOXAZOL-5-YL]-METHANOL
• Synonyms: [3-(3-FLUORO-PHENYL)-ISOXAZOL-5-YL]-METHANOL;3-(3-Fluorophenyl)-5-Isoxazolemethanol;[3-(3-Fluorophenyl)-1,2-oxazol-5-yl]methanol
• CAS NO: 954240-02-9
• Molecular Formula: C₁₀H₈FNO₂
• Molecular Weight: 193.17
• Mol File: 954240-02-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 363.252°C at 760 mmHg
• Flash Point: 173.489°C
• Appearance: /
• Density: 1.299g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.554
• CAS DataBase Reference: [3-(3-FLUORO-PHENYL)-ISOXAZOL-5-YL]-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: [3-(3-FLUORO-PHENYL)-ISOXAZOL-5-YL]-METHANOL(954240-02-9)
• EPA Substance Registry System: [3-(3-FLUORO-PHENYL)-ISOXAZOL-5-YL]-METHANOL(954240-02-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 954240-02-9(Hazardous Substances Data)

Usage

General Description

[3-(3-Fluoro-phenyl)-isoxazol-5-yl]-methanol is a chemical compound with the molecular formula C10H8FNO2. It is a methanol derivative with an isoxazole ring substituted with a 3-fluorophenyl group. [3-(3-FLUORO-PHENYL)-ISOXAZOL-5-YL]-METHANOL has potential applications in pharmaceuticals and organic synthesis as a building block for the synthesis of various biologically active molecules. It may also have potential therapeutic properties due to its structural features. Further research and studies are needed to explore its potential uses and effects in various fields.

InChI:InChI=1/C10H8FNO2/c11-8-3-1-2-7(4-8)10-5-9(6-13)14-12-10/h1-5,13H,6H2

Upstream product

• 107-19-7 propargyl alcohol 
• 458-02-6 3-fluorobenzaldehyde oxime 
• 456-48-4 3-Fluorobenzaldehyde 
• 6175-54-8 hydroxy-1-propyne 

Downstream Products

• 1421869-66-0 C₂₅H₂₈F₂N₄O*ClH 
• 1421869-72-8 C₂₅H₂₈ClFN₄O*ClH 
• 1421869-78-4 C₂₅H₂₈ClFN₄O*ClH 
• 1421869-84-2 C₂₆H₃₁FN₄O₂*ClH 
• 1421869-90-0 C₂₅H₂₈F₂N₄O*ClH 
• 1421869-96-6 C₃₂H₃₃F₃N₄O*ClH 
• 1421870-02-1 C₂₇H₃₃FN₄O*ClH 
• 1421870-08-7 C₂₅H₂₈ClFN₄O*ClH 
• 1421869-60-4 C₂₅H₂₉FN₄O*ClH 
• 885273-52-9 C₁₀H₆FNO₂ 
• 883541-40-0 3-(3-fluorophenyl)-1,2-oxazole-5-carboxylic acid 
• 5301-01-9 3-(3-fluorophenyl)-5-bromomethylisoxazole 

Relevant articles and documents

Synthesis, cytotoxic activity and binding model analysis of novel isoxazole-docetaxel analogues with C3′-N modification

Structure–activity relationship (SAR) studies confirm that modifications at C-3′ position can lead to the development of highly potent novel taxoids. We designed and synthesized a series of novel isoxazole-docetaxel analogues A1–A5 by introducing isoxazol

Synthesis and bioactivity of novel isoxazole chalcone derivatives on tyrosinase and melanin synthesis in murine B16 cells for the treatment of vitiligo

A new series of chalcone derivatives 1–18, bearing isoxazole moieties were designed and synthesized, and biologically evaluated for their activity on mushroom tyrosinase and melanin synthesis in murine B16 cells. The result indicated that most of prepared compounds 1–18 showed potent activating effect on tyrosinase, especially for 1–2, 4, 6–7, 9 and 15. Among them, compounds 2, 4 and 9 demonstrated the best activity with EC50?=?1.3, 2.5 and 3.0?μmol·L?1respectively, much better than the positive control 8-methoxypsoralan (8-MOP, EC50?=?14.8?μmol·L?1); In B16 cells, all the tested compounds exhibited a stronger activity on melanogenesis than 8-MOP (with the value of 115%). It was interesting that derivatives substituted with halogen (1, 2, 4, 5, 7, 9) were generally more potent. Compounds 2 (463%) and 18 (438%) with 3 and 4-fold potency compared with 8-MOP respectively, were recognized as the most promising candidate hits for further pharmacological study of anti-vitiligo.