95445-66-2Relevant articles and documents
Synthesis of Novel Hybrid 4 H -Pyran-lipoic and 4 H -Pyran-azetidine Derivatives
Hernández-Borja, Fernando,Contreras, Leticia,López, Julio,Alcaraz, Yolanda,Cruz, David,Estrada-Soto, Samuel,Delgado, Francisco,Vázquez, Miguel A.
, p. 1020 - 1026 (2018)
In this study, a molecular hybridization strategy was used to design and synthesize two novel series of hybrid compounds: 4 H -pyran-lipoic and 4 H -pyran-azetidine, employing ammonium hydroxide and involving the participation of aldehydes, malononitrile, and compounds derived from β-ketoesters to obtain the products with good yields.
Dihydropyridine derivatives, their preparation and their use
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, (2008/06/13)
2-(Amino or methyl)-6-(methyl or amino)-4-(substituted phenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid esters have a specific class of heterocyclic groups as thealcohol moiety. These compounds have a variety of valuable activities, including antihypertensive and Ca++ -blocking activities, leading to their use for the treatment of circulatory and coronary disorders. They may be prepared by condensation of appropriate substituted benzylideneacetoacetic acid esters with appropriate amidinoacetic acid esters.
