95542-12-4

Basic information

• Product Name: 3H-Indol-3-one, 1-acetyl-1,2-dihydro-2-(phenylmethylene)-
• CAS NO: 95542-12-4
• Molecular Formula: C17H13NO2
• Molecular Weight: 263.296
• Mol File: 95542-12-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3H-Indol-3-one, 1-acetyl-1,2-dihydro-2-(phenylmethylene)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-Indol-3-one, 1-acetyl-1,2-dihydro-2-(phenylmethylene)-(95542-12-4)
• EPA Substance Registry System: 3H-Indol-3-one, 1-acetyl-1,2-dihydro-2-(phenylmethylene)-(95542-12-4)

Safety Data

• Hazardous Substances Data: 95542-12-4(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 64605-23-8 2'-amino-2-chloroacetophenone 
• 68095-22-7 N-(2-(2-chloroacetyl)phenyl)acetamide 
• 16800-68-3 1-acetyl-2,3-dihydro-1H-indol-3-one 
• 100-52-7 benzaldehyde 

Downstream Products

• 38073-42-6 (2Z)-2-(phenylmethylidene)-2,3-dihydro-1H-indol-3-one 
• 97583-93-2 5-acetyl-2-diacetylamino-4-phenyl-3-cyano-4H-pyrano<3,2-b>indole 
• 97583-99-8 5-acetyl-2-methoxy-4-phenyl-3-cyano-δ-carboline 
• 97583-94-3 2-acetylamino-4-phenyl-3-cyano-4H-pyrano<3,2-b>indole 
• 97583-98-7 4-phenyl-3-cyano-2-ethoxy-δ-carboline 
• 97583-92-1 4-phenyl-2-methoxy-3-cyano-δ-carboline 
• 95542-25-9 N-Acetyl-N-[2-(2-acetyl-5-phenyl-2H-[1,2,3]triazole-4-carbonyl)-phenyl]-acetamide 
• 95542-24-8 2-acetyl-4-(2-acetylaminobenzoyl)-5-phenyl-1,2,3-triazole 
• 95542-20-4 (2-Amino-phenyl)-(5-phenyl-2H-[1,2,3]triazol-4-yl)-methanone 

Relevant articles and documents

Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites

The potential of azaaurones as dual-stage antimalarial agents was investigated by assessing the effect of a small library of azaaurones on the inhibition of liver and intraerythrocytic lifecycle stages of the malaria parasite. The whole series was screened against the blood stage of a chloroquine-resistant Plasmodium falciparum strain and the liver stage of P. berghei, yielding compounds with dual-stage activity and sub-micromolar potency against erythrocytic parasites. Studies with genetically modified parasites, using a phenotypic assay based on the P. falciparum Dd2-ScDHODH line, which expresses yeast dihydroorotate dehydrogenase (DHODH), showed that one of the azaaurone derivatives has the potential to inhibit the parasite mitochondrial electron-transport chain. The global urgency in finding new therapies for malaria, especially against the underexplored liver stage, associated with chemical tractability of azaaurones, warrants further development of this chemotype. Overall, these results emphasize the azaaurone chemotype as a promising scaffold for dual-stage antimalarials.

NEW METHOD OF CONVERTING 1-ACETYLINDOLIN-3-ONE AND AROMATIC ALDEHYDES INTO o-AMINOPHENYL KETONES OF THE vic-TRIAZOLE SERIES

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