955422-25-0 Usage
Description
(3S,4R)-4-Amino-1,3-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) 3-ethyl ester, commonly known as Baclofen, is a derivative of γ-aminobutyric acid (GABA) that functions as a GABAB receptor agonist. It is a white crystalline solid with a molecular formula of C8H14N2O2 and a molecular weight of 170.21 g/mol.
Uses
Used in Pharmaceutical Industry:
Baclofen is used as a muscle relaxant and antispastic medication for the treatment of conditions such as multiple sclerosis, spinal cord injuries, and cerebral palsy. It works by inhibiting the transmission of signals from nerves to muscles, resulting in a reduction in muscle spasticity and tension.
Used in Neurological Disorders:
Baclofen is used to manage muscle stiffness, pain, and spasms associated with neurological disorders. Its ability to reduce muscle tone and spasticity makes it a valuable treatment option for patients with these conditions.
Used in Oral and Intrathecal Administration:
Baclofen is available in both oral and intrathecal forms, allowing for different methods of administration depending on the patient's needs and the severity of their condition. The oral form is typically used for mild to moderate spasticity, while the intrathecal form is reserved for more severe cases or when oral administration is not effective.
However, it is important to note that Baclofen may cause side effects such as drowsiness, dizziness, and weakness, and should be used with caution. Patients should consult with their healthcare provider to determine the appropriate dosage and administration method for their specific condition.
Check Digit Verification of cas no
The CAS Registry Mumber 955422-25-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,5,4,2 and 2 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 955422-25:
(8*9)+(7*5)+(6*5)+(5*4)+(4*2)+(3*2)+(2*2)+(1*5)=180
180 % 10 = 0
So 955422-25-0 is a valid CAS Registry Number.
955422-25-0Relevant articles and documents
Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit
Zbinden, Katrin Groebke,Anselm, Lilli,Banner, David W.,Benz, Joerg,Blasco, Francesca,Decoret, Guillaume,Himber, Jacques,Kuhn, Bernd,Panday, Narendra,Ricklin, Fabienne,Risch, Philippe,Schlatter, Daniel,Stahl, Martin,Thomi, Stefan,Unger, Robert,Haap, Wolfgang
body text, p. 2787 - 2795 (2009/10/17)
Starting from a hit identified by focused screening, 3-aminopyrrolidine factor Xa inhibitors were designed. The binding mode as determined by X-ray structural analysis as well as the pharmacokinetic behaviour of selected compounds is discussed.
