95579-71-8

Basic information

• Product Name: Olmesartan
• Synonyms: 4-chloro-4-methyl-5-methylene-1,3-dioxolan-2-one;1,3-Dioxolan-2-one, 4-chloro-4-methyl-5-methylene-;AZATMint-B
• CAS NO: 95579-71-8
• Molecular Formula: C₅H₅ClO₃
• Molecular Weight: 148.55
• Mol File: 95579-71-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Olmesartan(CAS DataBase Reference)
• NIST Chemistry Reference: Olmesartan(95579-71-8)
• EPA Substance Registry System: Olmesartan(95579-71-8)

Safety Data

• Hazardous Substances Data: 95579-71-8(Hazardous Substances Data)

Usage

Uses

4-Chloro-4-methyl-5-methylene-1,3-dioxolan-2-one is an impurity in the synthesis of Olmesartan (O550000), An angiotensin II receptor antagonist. Used as an anti-hypertensive. Olmesartan Medoxomil Impurity 4.

Upstream product

• 37830-90-3 4,5-Dimethyl-1,3-dioxole-2-one 

Downstream Products

• 80841-78-7 4-chloromethyl-5-methyl-1,3-dioxol-2-one 

Relevant articles and documents

A 4 - chloro methyl -5 - methyl - 1, 3 - dioxo heterocyclic pentene -2 - one purification method

The invention discloses a purification method of 4-chloromethyl-5-methyl-1,3-dioxole-2-ketone. The purification method comprises the following steps of dissolving a crude product of 4-chloromethyl group-5-methyl-1,3-dioxole-2-ketone into a mixed solvent of methyl alcohol, ethyl alcohol, isopropyl alcohol and tertiary butanol for crystallizing for 0-24 hours at a temperature of -10-0 DEG C, and filtering to acquire the 4-chloromethyl-5-methyl-1,3-dioxole-2-ketone. The purification method has the characteristics of low cost, good refining effect, high yield, low requirement on equipment and simplicity and convenience in operation and is suitable for industrial production.

A Convenient and Practical Preparation of 4-Chloromethyl-5-methyl-1,3-dioxol-2-one

A new synthetic method for 4-chloromethyl-5-methyl-1,3-dioxol-2-one (1c), which is useful for preparing prodrugs, has been developed.Ene-chlorination of 4,5-dimethyl-1,3-dioxol-2-one (2) with chlorine or sulfuryl chloride afforded 4-chloro-4-methyl-5-methylene-1,3-dioxolan-2-one (3) in good yield.Compound 3 underwent allylic rearrangement to afford 1c quantitatively.The overall yield of 1c from 2 was approximately 80percent. Keywords---4-chloromethyl-5-methyl-1,3-dioxol-2-one; 4,5-dimethyl-1,3-dioxol-2-one; 4-chloro-4-methyl-5-methylene-1,3-dioxolan-2-one; ene-chlorination; allylic rearrangement; (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl group; promoiety; prodrug