957204-67-0

Basic information

• Product Name: 3-(2,4-DIFLUORO-PHENYL)-PROPAN-1-OL
• Synonyms: 3-(2,4-DIFLUORO-PHENYL)-PROPAN-1-OL
• CAS NO: 957204-67-0
• Molecular Formula: C₉H₁₀F₂O
• Molecular Weight: 172.1719064
• Mol File: 957204-67-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(2,4-DIFLUORO-PHENYL)-PROPAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2,4-DIFLUORO-PHENYL)-PROPAN-1-OL(957204-67-0)
• EPA Substance Registry System: 3-(2,4-DIFLUORO-PHENYL)-PROPAN-1-OL(957204-67-0)

Safety Data

• Hazardous Substances Data: 957204-67-0(Hazardous Substances Data)

Usage

Description

3-(2,4-DIFLUORO-PHENYL)-PROPAN-1-OL, a chemical compound with the molecular formula C9H9F2O, is a colorless liquid that serves as a valuable building block in the synthesis of various pharmaceuticals and organic compounds. Classified as a secondary alcohol, its hydroxyl group is attached to a carbon atom bonded to two other carbon atoms, contributing to its unique structure and potential applications in medicinal chemistry and drug discovery.

Uses

Used in Pharmaceutical Synthesis:
3-(2,4-DIFLUORO-PHENYL)-PROPAN-1-OL is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new and potentially beneficial molecules.
Used in Organic Compounds Synthesis:
In the field of organic chemistry, 3-(2,4-DIFLUORO-PHENYL)-PROPAN-1-OL is utilized as a precursor for the production of various organic compounds, highlighting its versatility and importance in chemical research and development.
Used in Medicinal Chemistry and Drug Discovery:
3-(2,4-DIFLUORO-PHENYL)-PROPAN-1-OL is employed as a valuable building block in medicinal chemistry and drug discovery, where its unique structure aids in the creation of innovative therapeutic agents.
It is crucial to handle 3-(2,4-DIFLUORO-PHENYL)-PROPAN-1-OL with care due to its potential harmful effects if ingested or inhaled, and its ability to cause skin and eye irritation.

Upstream product

• 75-21-8 oxirane 
• 23915-07-3 1-(bromomethyl)-2,4-difluorobenzene 
• 134672-70-1 3-(2,4-difluorophenyl)-propionic acid 
• 288100-99-2 3-(2,4-difluorophenyl)-2-propyn-1-ol 

Downstream Products

• 1057678-43-9 1-(3-bromopropyl)-2,4-difluorobenzene 
• 1057670-89-9 C₉H₈F₂O 
• 957204-68-1 3-(2,4-Difluorophenyl)-1-methanesulfonyloxypropane 
• 156868-39-2 1-(1,3-Difluoro-5,6,7,8-tetrahydro-5,5-dimethyl-2-naphthalenyl)ethanone 

Relevant articles and documents

Air-Stable PdI Dimer Enabled Remote Functionalization: Access to Fluorinated 1,1-Diaryl Alkanes with Unprecedented Speed

While remote functionalization via chain walking has the potential to enable access to molecules via novel disconnections, such processes require relatively long reaction times and can be in need of elevated temperatures. This work features a remote arylation in less than 10 min reaction time at room temperature over a distance of up to 11 carbons. The unprecedented speed is enabled by the air-stable PdI dimer [Pd(μ-I)(PCy2tBu)]2, which in contrast to its PtBu3 counterpart does not trigger direct coupling at the initiation site, but regioconvergent and chemoselective remote functionalization to yield valuable fluorinated 1,1-diaryl alkanes. Our combined experimental and computational studies rationalize the origins of switchability, which are primarily due to differences in dispersion interactions.

2-AMINO-1,3,4-THIADIAZINE AND 2-AMINO-1,3,4-OXADIAZINE BASED ANTIFUNGAL AGENTS

The invention provides a compound which is a diazine of formula (I) or a tautomer thereof, or a pharmaceutically acceptable salt thereof, for use as an antifungal agent: (I) wherein X, N', C', A and E are as defined herein. The invention also provides a compound of Formula (I) as defined herein.

HETEROARYLAMIDE LOWER CARBOXYLIC ACID DERIVATIVE

To provide a novel compound which has S1P receptor agonistic activity, exhibits excellent immunosuppressing effect, gives less adverse side effects, and can be orally administered. The invention provides a compound represented by general formula (I) (wherein A is a single bond, -O-, or - CH2-; R1 represents a hydrogen atom or a C1-C6 alkyl group, and V represents any one group selected from among the following groups (1) to (3) : (1) -G1-, (2) -G2-N(R2) -G3-, and (3) a group represented by formula 2, wherein each of Z1 and Z2 represents a hydrogen atom or a C1-C6 alkyl group, Z3 represents a hydrogen or the like, Q represents -CH2-O- or the like, and Y represents a group represented by foumula 3, a salt thereof, or a solvate thereof.