95724-98-4

Basic information

• Product Name: 2-(4-cyanophenyl)-N,N-diethyl-2-oxoacetamide
• Synonyms: 2-(4-cyanophenyl)-N,N-diethyl-2-oxoacetamide
• CAS NO: 95724-98-4
• Molecular Weight: 230.266
• Mol File: 95724-98-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(4-cyanophenyl)-N,N-diethyl-2-oxoacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-cyanophenyl)-N,N-diethyl-2-oxoacetamide(95724-98-4)
• EPA Substance Registry System: 2-(4-cyanophenyl)-N,N-diethyl-2-oxoacetamide(95724-98-4)

Safety Data

• Hazardous Substances Data: 95724-98-4(Hazardous Substances Data)

Upstream product

• 201230-82-2 carbon monoxide 
• 3058-39-7 4-iodobenzonitrile 
• 109-89-7 diethylamine 
• 623-00-7 4-bromobenzenecarbonitrile 

Relevant articles and documents

Pd-Catalyst Containing a Hemilabile P,C-Hybrid Ligand in Amino Dicarbonylation of Aryl Halides for Synthesis of α-Ketoamides

The amino dicarbonylation of aryl halides affording α-ketoamides with Pd catalysts is highly dependent on the stereoelectronic properties of the involved ligands. Ionic diphosphine ligand L4 can serve as precursor of a hemilabile P,C (phosphine, carbene)-hybrid ligand to form a stable Pd(II)-complex, Pd-L4. In contrast, analogues L1-L3 with a similar 1-(thiophen-3-yl)-benzimidazolyl skeleton behave as typical (mono/di)phosphines. The catalytic system resulting from the complexation of PdCl2(MeCN)2 and L4 exhibits good catalytic performance in terms of aryl iodides conversion (81-95%) and α-ketoamide selectivity (80-91%), as well as the available recyclability in the RTIL of [Bpy]BF4. The in situ FT-IR analysis reveals that the PdCl2(MeCN)2-L4 catalytic system favors the amino dicarbonylation toward α-ketoamides according to the proposed mechanism of cycle I, which involves two independent CO-insertion steps.