95734-82-0 Usage
Description
Nedaplatin, a novel second generation platinum complex, was marketed
in Japan for the treatment of a variety of cancers including: head and neck, small-cell
and non-small cell lung, oesophageal, prostatic, testicular, ovarian, cervical, bladder,
and uterine cancers. Platinum anticancer agents, prototyped by cisplatin, have been
reported to be hydrolyzed to the mono- or diaquated species of diamine platinum which
react with nucleophilic sites on DNA to cause intrastrand and interstrand crosslinks and
DNA-protein crosslinks, which result in cytotoxicity. Nedaplatin was reportedly more
active than cisplatin against several solid tumors while sharing less nephro- and
gastrointestinal toxicity to cisplatin in viva The minimal renal toxicity displayed by
nedaplatin allows its use in patients with deteriorated renal function.
Originator
Shionogi (Japan)
Uses
Nedaplatin is a platinum complex that has potent antineoplatic activity.
Brand name
Aqupla
Pharmaceutical Applications
Nedaplatin, cis-diammineglycolatoplatinum(II), is structurally similar to carboplatin.
The chemical structure consists of a central platinum(II) atom with two cis-ammonia groups as nonleaving
groups and – in contrast to carboplatin – the dianionic form of glycolic acid as the leaving group. Nedaplatin
has been approved for the clinical use in the Japanese market for the treatment of head and neck, testicular,
ovarian, lung and cervical cancer. It is typically administered by IV injection and its dose-limiting side effect
is myelosuppression.
Check Digit Verification of cas no
The CAS Registry Mumber 95734-82-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,5,7,3 and 4 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 95734-82:
(7*9)+(6*5)+(5*7)+(4*3)+(3*4)+(2*8)+(1*2)=170
170 % 10 = 0
So 95734-82-0 is a valid CAS Registry Number.
InChI:InChI=1/C2H3O3.2H2N.Pt/c3-1-2(4)5;;;/h1H2,(H,4,5);2*1H2;/q3*-1;+4/p-1/rC2H6N2O3Pt/c3-8(4)6-1-2(5)7-8/h1,3-4H2
95734-82-0Relevant articles and documents
Theoretical investigations and density functional theory based quantitative structure-activity relationships model for novel cytotoxic platinum(IV) complexes
Varbanov, Hristo P.,Jakupec, Michael A.,Roller, Alexander,Jensen, Frank,Galanski, Markus,Keppler, Bernhard K.
, p. 330 - 344 (2013)
Octahedral platinum(IV) complexes are promising candidates in the fight against cancer. In order to rationalize the further development of this class of compounds, detailed studies on their mechanisms of action, toxicity, and resistance must be provided and structure-activity relationships must be drawn. Herein, we report on theoretical and QSAR investigations of a series of 53 novel bis-, tris-, and tetrakis(carboxylato)platinum(IV) complexes, synthesized and tested for cytotoxicity in our laboratories. The hybrid DFT functional wb97x was used for optimization of the structure geometry and calculation of the descriptors. Reliable and robust QSAR models with good explanatory and predictive properties were obtained for both the cisplatin sensitive cell line CH1 and the intrinsically cisplatin resistant cell line SW480, with a set of four descriptors.
